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Details on Person UniProt:Q9NZ01 TECR

Class:Id	ReferenceGeneProduct:56014
_chainChangeLog	chain:1-308 added on Fri February 6 2015
_displayName	UniProt:Q9NZ01 TECR
_timestamp	2025-02-21 18:42:44
chain	chain:1-308
checksum	120AD0883820784D
comment	FUNCTION Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (PubMed:25049234). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (PubMed:12482854). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (PubMed:12482854). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (PubMed:12482854). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (PubMed:12482854). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (PubMed:25049234).CATALYTIC ACTIVITY a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)CATALYTIC ACTIVITY octadecanoyl-CoA + NADP(+) = (2E)-octadecenoyl-CoA + NADPH + H(+)CATALYTIC ACTIVITY (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + NADPH + H(+) = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)CATALYTIC ACTIVITY (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADPH + H(+) = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)CATALYTIC ACTIVITY (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + NADPH + H(+) = (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)CATALYTIC ACTIVITY (2E)-hexadecenoyl-CoA + NADPH + H(+) = hexadecanoyl-CoA + NADP(+)PATHWAY Lipid metabolism; fatty acid biosynthesis.PATHWAY Lipid metabolism; sphingolipid metabolism.SUBUNIT Interacts with ELOVL1 and LASS2 (PubMed:20937905). Interacts with HACD1 and HACD2 (via the third lumenal loop), but not with HACD3 and HACD4 (PubMed:38422897). Interacts with ELOVL1, ELOVL2, ELOVL3, ELOVL5 and ELOVL7 in the presence of acyl-CoA; interaction with HACD1/2 and that with ELOVLs are mutually exclusive (PubMed:38422897).INTERACTION Expressed in most tissues tested. Highly expressed in skeletal muscle.PTM Glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the steroid 5-alpha reductase family.
description	recommendedName: fullName evidence="11"Very-long-chain enoyl-CoA reductase ecNumber evidence="4"1.3.1.93 alternativeName: Synaptic glycoprotein SC2 alternativeName: Trans-2,3-enoyl-CoA reductase shortName: TER
geneName	TECR GPSN2 SC2
identifier	Q9NZ01
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Disease variant Endoplasmic reticulum Fatty acid biosynthesis Fatty acid metabolism Intellectual disability Lipid biosynthesis Lipid metabolism Membrane NADP Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Sphingolipid metabolism Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	TECR
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8993937] ENSEMBL:ENSG00000099797 TECR [Homo sapiens]
secondaryIdentifier	TECR_HUMAN B2RD55 O75350 Q6IBB2 Q9BWK3 Q9Y6P0
sequenceLength	308
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:148239] UniProt:Q9NZ01-2 TECR [Homo sapiens] [ReferenceIsoform:414929] UniProt:Q9NZ01-1 TECR [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:548663] TECR [endoplasmic reticulum membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q9NZ01 TECR (56014)