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Details on Person UniProt:O14653 GOSR2
| Class:Id | ReferenceGeneProduct:55980 |
|---|---|
| _chainChangeLog | chain:1-212 added on Fri February 6 2015 |
| _displayName | UniProt:O14653 GOSR2 |
| _timestamp | 2024-11-03 20:10:06 |
| chain | chain:1-212 |
| checksum | 4D5585CF858A610F |
| comment | FUNCTION Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.SUBUNIT Part of a unique SNARE complex composed of the Golgi SNAREs GOSR1, STX5 and YKT6 (By similarity). Interacts (via IxM motif) with SEC24C and SEC24D; mediates GOSR2 packaging into COPII-coated vesicles (PubMed:18843296). Interacts with BET1 (PubMed:34779586).INTERACTION Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus.ALTERNATIVE PRODUCTS The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the GOSR2 family. |
| description | recommendedName: Golgi SNAP receptor complex member 2 alternativeName: 27 kDa Golgi SNARE protein alternativeName: Membrin |
| geneName | GOSR2 GS27 |
| identifier | O14653 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Coiled coil Congenital muscular dystrophy Direct protein sequencing Disease variant Endoplasmic reticulum Epilepsy Golgi apparatus Membrane Neurodegeneration Protein transport Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GOSR2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5642204] ENSEMBL:ENSG00000108433 GOSR2 [Homo sapiens] |
| secondaryIdentifier | GOSR2_HUMAN D3DXJ5 D3DXJ6 Q8N4B8 Q96DA5 Q9BZZ4 |
| sequenceLength | 212 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:148236] UniProt:O14653-2 GOSR2 [Homo sapiens] [ReferenceIsoform:401241] UniProt:O14653-1 GOSR2 [Homo sapiens] [ReferenceIsoform:8973796] UniProt:O14653-3 GOSR2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:535472] GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] [Homo sapiens] [EntityWithAccessionedSequence:5689451] GOSR2 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:5689800] GOSR2 [ER to Golgi transport vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:6807755] GOSR2 [Golgi membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O14653 GOSR2 (55980)
