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Details on Person UniProt:P07492 GRP

Class:Id	ReferenceGeneProduct:55970
_chainChangeLog	signal peptide:1-23 added on Fri February 6 2015;peptide:24-50 added on Fri February 6 2015;peptide:41-50 added on Fri February 6 2015;propeptide:54-148 added on Fri February 6 2015
_displayName	UniProt:P07492 GRP
_timestamp	2024-11-03 19:51:25
chain	signal peptide:1-23 peptide:24-50 peptide:41-50 propeptide:54-148
checksum	6A9ED9E2748255BD
comment	FUNCTION Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake (By similarity). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).FUNCTION Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.INTERACTION In neurons of the retrotrapezoid nucleus/parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex.ALTERNATIVE PRODUCTS Belongs to the bombesin/neuromedin-B/ranatensin family.SEQUENCE CAUTION Gastrin-releasing peptide entry
description	recommendedName: Gastrin-releasing peptide shortName: GRP component recommendedName: Neuromedin-C alternativeName: GRP-10 alternativeName: fullName evidence="5"GRP18-27 /component
geneName	GRP
identifier	P07492
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Amidation Cell projection Cleavage on pair of basic residues Cytoplasmic vesicle Mast cell degranulation Proteomics identification Reference proteome Secreted Signal
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	GRP
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8999521] ENSEMBL:ENSG00000134443 GRP [Homo sapiens]
secondaryIdentifier	GRP_HUMAN P07491 P81553 Q14454 Q53YA0 Q9BSY7
sequenceLength	148
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:148231] UniProt:P07492-2 GRP [Homo sapiens] [ReferenceIsoform:148232] UniProt:P07492-3 GRP [Homo sapiens] [ReferenceIsoform:402538] UniProt:P07492-1 GRP [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:375358] GRP(24-50) [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P07492 GRP (55970)