Query author contributions in Reactome
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Details on Person UniProt:P30550 GRPR
| Class:Id | ReferenceGeneProduct:55968 |
|---|---|
| _chainChangeLog | chain:1-384 added on Fri February 6 2015 |
| _displayName | UniProt:P30550 GRPR |
| _timestamp | 2024-11-03 20:14:39 |
| chain | chain:1-384 |
| checksum | 70A75F11D9C82F19 |
| comment | FUNCTION Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).SUBCELLULAR LOCATION Highly expressed in pancreas (PubMed:11245983). Also expressed in stomach, adrenal cortex and brain (PubMed:11245983). In brain, expressed in cells throughout the cortex (PubMed:34610277).SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: Gastrin-releasing peptide receptor shortName: GRP-R alternativeName: GRP-preferring bombesin receptor |
| geneName | GRPR |
| identifier | P30550 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Lipoprotein Membrane Palmitate Phosphoprotein Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GRPR |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988418] ENSEMBL:ENSG00000126010 GRPR [Homo sapiens] |
| secondaryIdentifier | GRPR_HUMAN B2R910 |
| sequenceLength | 384 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:375363] GRPR [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P30550 GRPR (55968)
