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Details on Person UniProt:O00270 GPR31
| Class:Id | ReferenceGeneProduct:55818 |
|---|---|
| _chainChangeLog | chain:1-319 added on Fri February 6 2015 |
| _displayName | UniProt:O00270 GPR31 |
| _timestamp | 2024-11-03 20:10:07 |
| chain | chain:1-319 |
| checksum | 2ACD0350AD7FB53A |
| comment | FUNCTION High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers (PubMed:21712392, PubMed:29227475). 12-S-HETE is a eicosanoid, a 12-lipoxygenase (ALOX12) metabolite of arachidonic acid, involved in many physiologic and pathologic processes (PubMed:26965684, PubMed:28619714, PubMed:29227475). 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways leading to cell growth (PubMed:21712392, PubMed:29227475). Plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM (PubMed:28619714). Contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1(+) phagocytes for the uptake of luminal antigens (By similarity). Acts also as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury (PubMed:29227475).FUNCTION Proton-sensing G protein-coupled receptor.SUBUNIT Interacts with KRAS; in a farnesylation-dependent manner.INTERACTION Up-regulated in prostate cancer.SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor shortName evidence="13"12-(S)-HETE receptor shortName evidence="13"12-HETER alternativeName: fullName evidence="15"G-protein coupled receptor 31 alternativeName: fullName evidence="14"GPR31/12-HETER |
| geneName | GPR31 |
| identifier | O00270 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane G-protein coupled receptor Glycoprotein Lipid metabolism Membrane Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GPR31 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997190] ENSEMBL:ENSG00000120436 GPR31 [Homo sapiens] |
| secondaryIdentifier | GPR31_HUMAN B0M0K2 Q4VBL3 Q9NQ20 |
| sequenceLength | 319 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:3296239] GPR31 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O00270 GPR31 (55818)
