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Details on Person UniProt:P55259 GP2
| Class:Id | ReferenceGeneProduct:55816 |
|---|---|
| _chainChangeLog | signal peptide:1-28 added on Sat February 7 2015;chain:29-512 added on Sat February 7 2015;propeptide:513-537 added on Sat February 7 2015 |
| _displayName | UniProt:P55259 GP2 |
| _timestamp | 2026-02-20 21:49:24 |
| chain | signal peptide:1-28 chain:29-512 propeptide:513-537 |
| checksum | 8A6B6A0FC64F50B8 |
| comment | FUNCTION Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.SUBUNIT Interacts with SYCN (By similarity). Interacts with bacterial adhesin fimH (PubMed:19907495, PubMed:35273390).INTERACTION Secreted, after cleavage, in the pancreatic juice.ALTERNATIVE PRODUCTS Expressed in pancreas (at protein level) (PubMed:10760606, PubMed:8666297). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level) (PubMed:19907495).DOMAIN Each ZP domain consists of an N-terminal (ZP-N) and C-terminal (ZP-C) region connected by a flexible linker; the linker allows the ZP domain to wrap around the ZP-C subdomain of the preceding subunit.PTM N-glycosylated. Glycosylated Asn-65 may be required for interaction with bacterial adhesin fimH.CAUTION It is uncertain whether Met-1 or Met-8 is the initiator. |
| description | recommendedName: fullName evidence="20"Pancreatic secretory granule membrane major glycoprotein GP2 alternativeName: fullName evidence="20"Pancreatic zymogen granule membrane protein GP-2 alternativeName: ZAP75 |
| geneName | GP2 |
| identifier | P55259 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Cytoplasmic vesicle Disulfide bond EGF-like domain Endosome Glycoprotein GPI-anchor Immunity Innate immunity Lipoprotein Membrane Proteomics identification Receptor Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | GP2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997187] ENSEMBL:ENSG00000169347 GP2 [Homo sapiens] |
| secondaryIdentifier | GP2_HUMAN A6NFM9 A6NJA8 Q13338 Q9UIF1 |
| sequenceLength | 537 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:148105] UniProt:P55259-2 GP2 [Homo sapiens] [ReferenceIsoform:385173] UniProt:P55259-3 GP2 [Homo sapiens] [ReferenceIsoform:385174] UniProt:P55259-4 GP2 [Homo sapiens] [ReferenceIsoform:404440] UniProt:P55259-1 GP2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8940416] GP2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8940732] GPI-GP2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8941111] cleaved GPI-GP2 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9922809] GP2 [zymogen granule] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:8940784] L-asparagine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 512 [GroupModifiedResidue:8941079] L-asparagine amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 512 |
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No pathways have been reviewed or authored by UniProt:P55259 GP2 (55816)
