Query author contributions in Reactome
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Details on Person UniProt:O00155 GPR25
| Class:Id | ReferenceGeneProduct:55812 |
|---|---|
| _chainChangeLog | chain:1-361 added on Fri February 6 2015 |
| _displayName | UniProt:O00155 GPR25 |
| _timestamp | 2026-02-20 21:49:27 |
| chain | chain:1-361 |
| checksum | C9C155A415B1DE9F |
| comment | FUNCTION Receptor for the C-X-C chemokine CXCL17, which plays a key role in lymphocyte homing (PubMed:39293486, PubMed:40279398). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway (PubMed:39293486). Activation by CXCL17 on lymphocytes activates the RhoA pathway, which regulates cytoskeletal dynamics and integrins, mediating lymphocyte recruitment into the respiratory, upper gastrointestinal, biliary and genito-urinary tracts (PubMed:39293486).INTERACTION Present on activated B- and T-cells.INDUCTION Induced on innate lymphocytes before emigration to the periphery.SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: fullName evidence="6"C-X-C chemokine receptor GPR25 alternativeName: fullName evidence="6"G-protein coupled receptor 25 |
| geneName | GPR25 |
| identifier | O00155 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Chemotaxis Disulfide bond G-protein coupled receptor Immunity Membrane Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | GPR25 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993060] ENSEMBL:ENSG00000170128 GPR25 [Homo sapiens] |
| secondaryIdentifier | GPR25_HUMAN A0AVJ5 |
| sequenceLength | 361 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6805220] GPR25 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O00155 GPR25 (55812)
