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Details on Person UniProt:Q14330 GPR18
| Class:Id | ReferenceGeneProduct:55800 |
|---|---|
| _chainChangeLog | chain:1-331 added on Fri February 6 2015 |
| _displayName | UniProt:Q14330 GPR18 |
| _timestamp | 2025-05-21 21:05:35 |
| chain | chain:1-331 |
| checksum | 5B0B755A74FBBB36 |
| comment | FUNCTION G protein-coupled receptor (GPCR) that plays a role in diverse physiological processes particularly within the immune and nervous systems (PubMed:21732409, PubMed:26195725). Becomes active when triggered by various endogenous ligands including endocannabinoid N-arachidonyl glycine (NAGly), delta-9-tetrahydrocannabinol or resolvin D2/RvD2 derived from the omega-3 fatty acid docosahexaenoic acid (DHA) (PubMed:16844083, PubMed:24762058, PubMed:26195725, PubMed:27572937). Upon RvD2 binding, facilitates the resolution of inflammation, aiding in tissue repair and homeostasis. Mechanistically, RvD2 ligation initiates Galphas protein coupling, activation of cAMP-PKA signaling pathway and phosphorylation of STAT3, leading to RvD2-stimulated macrophage phagocytosis (PubMed:27994074). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937). Activation by N-arachidonoyl glycine (NAGly) can also induce apoptosis in macrophages (By similarity). Plays a role in homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intestine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Also participates in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity).SUBCELLULAR LOCATION Expressed in midpiece of spermatozoon (at protein level) (PubMed:27572937). Most abundant in testis and spleen (PubMed:16844083). Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells (PubMed:16844083).SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: N-arachidonyl glycine receptor shortName: NAGly receptor alternativeName: G-protein coupled receptor 18 |
| geneName | GPR18 GPCRW |
| identifier | Q14330 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Cytoplasmic vesicle Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | GPR18 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997189] ENSEMBL:ENSG00000125245 GPR18 [Homo sapiens] |
| secondaryIdentifier | GPR18_HUMAN Q6GTM3 Q96HI6 Q9H2L2 |
| sequenceLength | 331 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:517529] GPR18 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q14330 GPR18 (55800)
