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Details on Person Defective AHCY does not hydrolyse AdoHcy

Class:IdFailedReaction:5579084
_displayNameDefective AHCY does not hydrolyse AdoHcy
_doReleaseTRUE
_timestamp2019-02-25 14:03:18
authored[InstanceEdit:5579090] Jassal, Bijay, 2014-06-06
catalystActivity[CatalystActivity:9638059] adenosylhomocysteinase activity of AHCY mutants:NAD+ tetramer [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:5579090] Jassal, Bijay, 2014-06-06
disease[Disease:5579115] hypermethioninemia
edited[InstanceEdit:5579090] Jassal, Bijay, 2014-06-06
entityFunctionalStatus[EntityFunctionalStatus:5579113] loss_of_function of AHCY mutants:NAD+ tetramer [cytosol]
input[SimpleEntity:71285] AdoHcy [cytosol]
[SimpleEntity:29356] H2O [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:5579036] Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions
[LiteratureReference:5579074] Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength
[LiteratureReference:5579078] S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism
modified[InstanceEdit:5580323] Jassal, Bijay, 2014-06-10
[InstanceEdit:5627273] Jassal, Bijay, 2014-10-17
[InstanceEdit:5632882] Matthews, Lisa, 2014-10-29
[InstanceEdit:5634120] Jassal, Bijay, 2014-11-03
[InstanceEdit:5635733] Matthews, Lisa, 2014-11-07
[InstanceEdit:9638051] Jassal, Bijay, 2019-02-25
[InstanceEdit:9638057] Jassal, Bijay, 2019-02-25
[InstanceEdit:9638058] Jassal, Bijay, 2019-02-25
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDefective AHCY does not hydrolyse AdoHcy
normalReaction
releaseDate2014-12-11
reviewed[InstanceEdit:5634119] Nakaki, Toshio, 2014-11-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6781751] R-HSA-5579084.3
summation[Summation:5579071] Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, c...
systematicNameAHCY mutants do not hydrolyse AdoHcy
(hasEvent)[Pathway:5578997] Defective AHCY causes HMAHCHD [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778013] Update Tracker - [FailedReaction:5579084] Defective AHCY does not hydrolyse AdoHcy - v68:[addCatalystActivity]
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