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Details on Person Defective ACY1 does not hydrolyse mercapturic acids
| Class:Id | FailedReaction:5579081 |
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| _displayName | Defective ACY1 does not hydrolyse mercapturic acids |
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| _doRelease | TRUE |
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| _timestamp | 2019-02-25 14:16:49 |
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| authored | [InstanceEdit:5579090] Jassal, Bijay, 2014-06-06 |
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| catalystActivity | [CatalystActivity:9638060] aminoacylase activity of ACY1 mutants:Zn2+ dimer [cytosol] |
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| compartment | [Compartment:70101] cytosol |
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| created | [InstanceEdit:5579090] Jassal, Bijay, 2014-06-06 |
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| disease | [Disease:5579092] toxic encephalopathy |
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| edited | [InstanceEdit:5579090] Jassal, Bijay, 2014-06-06 |
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| entityFunctionalStatus | [EntityFunctionalStatus:5579087] loss_of_function of ACY1 mutants:Zn2+ dimer [cytosol] |
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| input | [DefinedSet:5490236] AFXBO-NAC,AFNBO-NAC [cytosol]
[SimpleEntity:29356] H2O [cytosol] |
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| isChimeric | FALSE |
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| literatureReference | [LiteratureReference:5490294] Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family
[LiteratureReference:5579051] Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism
[LiteratureReference:5579107] Neurological findings in aminoacylase 1 deficiency |
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| modified | [InstanceEdit:5580323] Jassal, Bijay, 2014-06-10
[InstanceEdit:5627273] Jassal, Bijay, 2014-10-17
[InstanceEdit:5632882] Matthews, Lisa, 2014-10-29
[InstanceEdit:5634120] Jassal, Bijay, 2014-11-03
[InstanceEdit:5635733] Matthews, Lisa, 2014-11-07
[InstanceEdit:9638061] Jassal, Bijay, 2019-02-25
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
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| name | Defective ACY1 does not hydrolyse mercapturic acids |
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| normalReaction |
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| releaseDate | 2014-12-11 |
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| reviewed | [InstanceEdit:5634119] Nakaki, Toshio, 2014-11-03 |
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| reviewStatus | [ReviewStatus:9821382] five stars |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:6781750] R-HSA-5579081.3 |
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| summation | [Summation:5579059] Cytosolic aminocyclases 1 and 3 (ACY1,3) can hydrolyse N-acy... |
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| systematicName | ACY1 mutants do not hydrolyse AFXBO-NAC,AFNBO-NAC |
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| (hasEvent) | [Pathway:5579007] Defective ACY1 causes encephalopathy [Homo sapiens] |
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| (updatedInstance) | [_UpdateTracker:9778494] Update Tracker - [FailedReaction:5579081] Defective ACY1 does not hydrolyse mercapturic acids - v68:[addCatalystActivity] |
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