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Details on Person Importin-8 imports AGO2:miRNA into the nucleus

Class:IdReaction:5578744
_displayNameImportin-8 imports AGO2:miRNA into the nucleus
_doReleaseTRUE
_timestamp2025-10-08 19:38:19
authored[InstanceEdit:5578729] May, Bruce, 2014-05-30
catalystActivityReference[CatalystActivityReference:9643944] structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope] Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase
compartment[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
[Compartment:13231] nuclear envelope
created[InstanceEdit:5578738] May, Bruce, 2014-05-31
edited[InstanceEdit:5578729] May, Bruce, 2014-05-30
input[Complex:5578743] IPO8:AGO2:miRNA [cytosol] [Homo sapiens]
[Complex:180686] RAN:GTP [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9968063] D'Eustachio, Peter, 2025-10-08
isChimericFALSE
literatureReference[LiteratureReference:561218] Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells
[LiteratureReference:5578752] Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells
[LiteratureReference:5578698] Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs
[LiteratureReference:5578719] Importin 8 regulates the transport of mature microRNAs into the cell nucleus
[LiteratureReference:208383] A novel class of RanGTP binding proteins
[LiteratureReference:5579131] RNAi factors are present and active in human cell nuclei
[LiteratureReference:5621968] Specific and potent RNAi in the nucleus of human cells
[LiteratureReference:5621952] The double-stranded RNA binding domain of human Dicer functions as a nuclear localization signal
[LiteratureReference:5578961] Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus
modified[InstanceEdit:5578982] May, Bruce, 2014-06-06
[InstanceEdit:5579155] May, Bruce, 2014-06-07
[InstanceEdit:5615694] May, Bruce, 2014-07-29
[InstanceEdit:5617421] May, Bruce, 2014-08-06
[InstanceEdit:5619522] May, Bruce, 2014-08-25
[InstanceEdit:5621990] May, Bruce, 2014-09-06
[InstanceEdit:5621993] May, Bruce, 2014-09-06
[InstanceEdit:5690961] May, Bruce, 2015-05-02
[InstanceEdit:8865030] D'Eustachio, Peter, 2016-03-18
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9968062] D'Eustachio, Peter, 2025-10-08
[InstanceEdit:9968064] D'Eustachio, Peter, 2025-10-08
[InstanceEdit:9968067] D'Eustachio, Peter, 2025-10-08
nameImportin-8 imports AGO2:miRNA into the nucleus
output[Complex:5578695] AGO2:miRNA [nucleoplasm] [Homo sapiens]
[Complex:5578721] IPO8:RAN:GTP [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2014-09-30
reviewed[InstanceEdit:5619520] Li, Long-Cheng, 2014-08-25
[InstanceEdit:5621991] Stroynowska-Czerwinska, Anna, 2014-09-06
[InstanceEdit:9968066] Hill, David P, 2025-10-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5622600] R-HSA-5578744.5
structureModified[InstanceEdit:9968062] D'Eustachio, Peter, 2025-10-08
summation[Summation:5578972] The AGO2:miRNA complex is formed in the cytosol (Ohrt et al ...
(hasEvent)[Pathway:5578749] Transcriptional regulation by small RNAs [Homo sapiens]
(precedingEvent)[Reaction:5578742] AGO1,2:small RNA complexes interact with chromatin [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784620] Update Tracker - [Reaction:5578744] Importin-8 imports AGO2:miRNA into the nucleus - v53:[add_removeCatalystActivity]
[_UpdateTracker:9971869] Update Tracker - [Reaction:5578744] Importin-8 imports AGO2:miRNA into the nucleus - v95:[addCatalystActivity, modifyText]
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