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Details on Person UniProt:Q10469 MGAT2
| Class:Id | ReferenceGeneProduct:55780 |
|---|---|
| _chainChangeLog | chain:1-447 added on Fri February 6 2015 |
| _displayName | UniProt:Q10469 MGAT2 |
| _timestamp | 2026-02-20 22:12:28 |
| chain | chain:1-447 |
| checksum | 533B76D08BD8A572 |
| comment | FUNCTION Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans.CATALYTIC ACTIVITY an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)COFACTOR Protein modification; protein glycosylation.SUBUNIT Homodimer.SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the glycosyltransferase 16 (GT16) protein family.ONLINE INFORMATION Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
| description | recommendedName: Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase ecNumber evidence="4 5 6 7"2.4.1.143 alternativeName: Beta-1,2-N-acetylglucosaminyltransferase II alternativeName: GlcNAc-T II shortName: GNT-II alternativeName: Mannoside acetylglucosaminyltransferase 2 alternativeName: N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II |
| geneName | MGAT2 |
| identifier | Q10469 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Congenital disorder of glycosylation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Glycosyltransferase Golgi apparatus Manganese Membrane Metal-binding Proteomics identification Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | MGAT2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995540] ENSEMBL:ENSG00000168282 MGAT2 [Homo sapiens] |
| secondaryIdentifier | MGAT2_HUMAN B3KPC5 B3KQM0 |
| sequenceLength | 447 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:975830] MGAT2 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:4839784] MGAT2 K237N [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:4839804] MGAT2 S290F [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:4839821] MGAT2 H262R [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:4839827] MGAT2 N318D [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:4839829] MGAT2 C339* [Golgi membrane] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:4839777] L-serine 290 replaced with L-phenylalanine [NonsenseMutation:4839816] Nonsense mutation at L-cysteine 339 [ReplacedResidue:4839819] L-histidine 262 replaced with L-arginine [ReplacedResidue:4839832] L-lysine 237 replaced with L-asparagine [ReplacedResidue:4839838] L-asparagine 318 replaced with L-aspartic acid |
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No pathways have been reviewed or authored by UniProt:Q10469 MGAT2 (55780)
