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Details on Person KCNH2:KCNE transport K+ from cytosol to extracellular region

Class:Id	Reaction:5577237
_displayName	KCNH2:KCNE transport K+ from cytosol to extracellular region
_doRelease	TRUE
_timestamp	2026-02-27 21:18:28
authored	[InstanceEdit:5578924] Jassal, Bijay, 2014-06-05 [InstanceEdit:9977627] Vaglio, Arielle, 2025-08-19 [InstanceEdit:9977629] Gesino, Anthony, 2025-08-19
catalystActivity	[CatalystActivity:5577159] delayed rectifier potassium channel activity of KCNH2:KCNE [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5577230] Jassal, Bijay, 2014-05-29
edited	[InstanceEdit:5578924] Jassal, Bijay, 2014-06-05
input	[SimpleEntity:29804] K+ [cytosol]
internalReviewed	[InstanceEdit:9978791] Matthews, Lisa, 2026-01-07
isChimeric	FALSE
literatureReference	[LiteratureReference:5577166] A minK-HERG complex regulates the cardiac potassium current I(Kr) [LiteratureReference:5577151] MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
modified	[InstanceEdit:5578800] Jassal, Bijay, 2014-06-02 [InstanceEdit:5578934] Jassal, Bijay, 2014-06-05 [InstanceEdit:6809172] Jassal, Bijay, 2015-11-09 [InstanceEdit:9613229] Jassal, Bijay, 2018-07-12 [InstanceEdit:9628972] Jassal, Bijay, 2018-11-14 [InstanceEdit:9631986] Jassal, Bijay, 2018-12-12 [InstanceEdit:9690290] Jassal, Bijay, 2020-05-29 [InstanceEdit:9700774] Jassal, Bijay, 2020-09-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9977624] Matthews, Lisa, 2025-12-22 [InstanceEdit:9983893] Matthews, Lisa, 2026-02-27
name	KCNH2:KCNE transport K+ from cytosol to extracellular region
output	[SimpleEntity:74126] K+ [extracellular region]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:9977628] Negative regulation by 'Class III antiarrhythmics:KCNH2:KCNE [plasma membrane]'
regulationReference	[RegulationReference:9977631] Negative regulation by 'Class III antiarrhythmics:KCNH2:KCNE [plasma membrane]' Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6809173] Colotti, Gianni, 2015-11-09
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812355] R-HSA-5577237.8
structureModified	[InstanceEdit:9977624] Matthews, Lisa, 2025-12-22
summation	[Summation:5577127] Two potassium currents, I_Ks and I_Kr, p...
(hasEvent)	[Pathway:5576890] Phase 3 - rapid repolarisation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776556] Update Tracker - [Reaction:5577237] KCNH2:KCNE transport K+ from cytosol to extracellular region - v75:[removeRegulator] [_UpdateTracker:9778147] Update Tracker - [Reaction:5577237] KCNH2:KCNE transport K+ from cytosol to extracellular region - v68:[addRegulator] [_UpdateTracker:9778797] Update Tracker - [Reaction:5577237] KCNH2:KCNE transport K+ from cytosol to extracellular region - v67:[removeRegulator] [_UpdateTracker:9779037] Update Tracker - [Reaction:5577237] KCNH2:KCNE transport K+ from cytosol to extracellular region - v66:[addRegulator] [_UpdateTracker:9984608] Update Tracker - [Reaction:5577237] KCNH2:KCNE transport K+ from cytosol to extracellular region - v96:[removeRegulator]
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No pathways have been reviewed or authored by KCNH2:KCNE transport K+ from cytosol to extracellular region (5577237)