Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Cardiac conduction

Class:IdPathwayDiagram:5576889
_displayNameDiagram of Cardiac conduction
_timestamp2025-12-22 16:45:10
created[InstanceEdit:5576887] Jassal, Bijay, 2014-05-27
height1063
modified[InstanceEdit:5578931] Jassal, Bijay, 2014-06-05
[InstanceEdit:5578959] Jassal, Bijay, 2014-06-05
[InstanceEdit:5578985] Jassal, Bijay, 2014-06-06
[InstanceEdit:5578994] Jassal, Bijay, 2014-06-06
[InstanceEdit:5617175] Jassal, Bijay, 2014-08-05
[InstanceEdit:5617216] Jassal, Bijay, 2014-08-06
[InstanceEdit:5617240] Jassal, Bijay, 2014-08-06
[InstanceEdit:5634737] Jassal, Bijay, 2014-11-05
[InstanceEdit:5674040] Jassal, Bijay, 2015-02-10
[InstanceEdit:5674043] Jassal, Bijay, 2015-02-10
[InstanceEdit:5678254] Jassal, Bijay, 2015-02-23
[InstanceEdit:5678268] Jassal, Bijay, 2015-02-23
[InstanceEdit:5678572] Jassal, Bijay, 2015-02-24
[InstanceEdit:5693193] Jassal, Bijay, 2015-05-14
[InstanceEdit:5693225] Jassal, Bijay, 2015-05-14
[InstanceEdit:6784599] Jassal, Bijay, 2015-06-22
[InstanceEdit:6784949] Jassal, Bijay, 2015-06-23
[InstanceEdit:6797413] Jassal, Bijay, 2015-09-10
[InstanceEdit:6809078] Jassal, Bijay, 2015-11-09
[InstanceEdit:6809101] Jassal, Bijay, 2015-11-09
[InstanceEdit:6809102] Jassal, Bijay, 2015-11-09
[InstanceEdit:6809128] Jassal, Bijay, 2015-11-09
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8858249] Jassal, Bijay, 2016-02-18
[InstanceEdit:8858250] Jassal, Bijay, 2016-02-18
[InstanceEdit:8858251] Jassal, Bijay, 2016-02-18
[InstanceEdit:8943671] Jassal, Bijay, 2016-10-28
[InstanceEdit:9016830] Jassal, Bijay, 2017-08-16
[InstanceEdit:9612563] Jassal, Bijay, 2018-06-28
[InstanceEdit:9612683] Jassal, Bijay, 2018-06-29
[InstanceEdit:9612695] Jassal, Bijay, 2018-06-29
[InstanceEdit:9612765] Jassal, Bijay, 2018-06-29
[InstanceEdit:9613057] Jassal, Bijay, 2018-07-09
[InstanceEdit:9613229] Jassal, Bijay, 2018-07-12
[InstanceEdit:9613308] Jassal, Bijay, 2018-07-13
[InstanceEdit:9613835] Jassal, Bijay, 2018-07-19
[InstanceEdit:9614020] Jassal, Bijay, 2018-07-23
[InstanceEdit:9614180] Jassal, Bijay, 2018-07-24
[InstanceEdit:9614182] Jassal, Bijay, 2018-07-24
[InstanceEdit:9628973] Jassal, Bijay, 2018-11-14
[InstanceEdit:9629522] Jassal, Bijay, 2018-11-21
[InstanceEdit:9631986] Jassal, Bijay, 2018-12-12
[InstanceEdit:9670546] Jassal, Bijay, 2019-12-10
[InstanceEdit:9670547] Jassal, Bijay, 2019-12-10
[InstanceEdit:9670573] Jassal, Bijay, 2019-12-11
[InstanceEdit:9690290] Jassal, Bijay, 2020-05-29
[InstanceEdit:9691578] Jassal, Bijay, 2020-06-17
[InstanceEdit:9699105] Jassal, Bijay, 2020-09-11
[InstanceEdit:9700774] Jassal, Bijay, 2020-09-16
[InstanceEdit:9727399] Jassal, Bijay, 2021-04-16
[InstanceEdit:9727563] Jassal, Bijay, 2021-04-19
[InstanceEdit:9727622] Jassal, Bijay, 2021-04-19
[InstanceEdit:9977624] Matthews, Lisa, 2025-12-22
representedPathway[Pathway:5576891] Cardiac conduction [Homo sapiens]
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</Properties> <OldBounds> <Bounds id="1168" bounds="98 95 186 91" /> </OldBounds> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1176" reactomeId="9614108" position="669 23" bounds="604 6 131 34" textPosition="615 5" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>Class IV antihypertensives</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1177" reactomeId="9614114" position="621 134" bounds="561 110 121 48" textPosition="565 108" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>Class IV antihypertensives:LTCC multimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1188" reactomeId="9613840" position="1290 40" bounds="1230 22 120 36" textPosition="1236 22" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>Class III (KCNA5) 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textPosition="1675 771" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MME:Zn2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1352" reactomeId="9727404" position="1945 837" bounds="1895 826 100 23" textPosition="1908 820"> <Properties> <displayName>NPPA(131-151)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1353" reactomeId="9727400" position="1946 796" bounds="1896 785 100 23" textPosition="1909 779"> <Properties> <displayName>NPPA(124-130)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemicalDrug id="1355" reactomeId="9727588" position="1542 813" bounds="1502 798 80 31" textPosition="1506 802" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>sacubitrilat</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableComplex id="1356" reactomeId="9727599" position="1700 857" bounds="1664 835 73 45" textPosition="1665 830" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>MME:Zn2+:sacubitrilat</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="1441" reactomeId="13977" position="1363 710" bounds="1309 664 109 92" textPosition="1314 677" bgColor="250 240 240" lineColor="255 153 102" insets="1319 674 89 73"> <Properties> <displayName>lipid droplet</displayName> </Properties> <Components> <Component id="1444" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemicalDrug id="1443" reactomeId="9727597" position="1542 615" bounds="1508 600 69 31" textPosition="1512 604" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>sacubitril</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableComplex id="1444" reactomeId="9727569" position="1420 720" bounds="1382 709 77 23" textPosition="1382 710" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CES1 trimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1450" reactomeId="29356" position="1502 654" bounds="1481 639 43 31" textPosition="1485 643" /> <org.gk.render.RenderableChemical id="1456" reactomeId="30203" position="1497 772" bounds="1474 757 46 31" textPosition="1478 761"> <Properties> <displayName>EtOH</displayName> </Properties> </org.gk.render.RenderableChemical> </Nodes> <Edges> <org.gk.render.RenderableReaction id="16" reactomeId="1296046" points="107 674, 165 668, 214 674" position="165 668" lineWidth="1.0"> <Inputs> <Input id="18" /> </Inputs> <Outputs> <Output id="17" /> </Outputs> <Catalysts> <Catalyst id="19" points="165 646" /> </Catalysts> <Properties> <displayName>KCNJs transport K+ from the extracellular region to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="20" reactomeId="5578910" points="214 679, 165 685, 107 678" position="165 685" lineWidth="1.0"> <Inputs> <Input id="17" /> </Inputs> <Outputs> <Output id="18" /> </Outputs> <Catalysts> <Catalyst id="21" points="165 709" /> </Catalysts> <Properties> <displayName>KCNK dimers transport K+ from cytosol to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="22" reactomeId="5576895" points="481 97, 481 133, 479 199" position="481 133" lineWidth="1.0"> <Inputs> <Input id="23" /> </Inputs> <Outputs> <Output id="24" /> </Outputs> <Catalysts> <Catalyst id="25" points="415 125" /> </Catalysts> <Inhibitors> <Inhibitor id="306" points="388 283" /> <Inhibitor id="1168" points="250 181, 318 202" /> </Inhibitors> <Activators> <Activator id="26" points="575 188" /> <Activator id="275" points="388 194" /> </Activators> <Properties> <displayName>SCNAs:SNCBs transport Na+ from extracellular region to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="27" reactomeId="5577213" points="853 110, 853 139, 852 178" position="853 139" lineWidth="1.0"> <Inputs> <Input id="28" /> </Inputs> <Outputs> <Output id="29" /> </Outputs> <Catalysts> <Catalyst id="30" points="803 137" /> </Catalysts> <Inhibitors> <Inhibitor id="1177" points="685 152, 767 179" /> </Inhibitors> <Properties> <displayName>LTCC multimer transports Ca2+ from extracellular region to cytosol</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="34" reactomeId="5577234" points="950 173, 950 137, 950 91" position="950 137" lineWidth="1.0"> <Inputs> <Input id="38" /> </Inputs> <Outputs> <Output id="36" /> </Outputs> <Catalysts> <Catalyst id="35" points="975 137" /> </Catalysts> <Properties> <displayName>KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="39" reactomeId="5577050" points="1598 172, 1584 138, 1601 98" position="1584 138" lineWidth="1.0"> <Inputs> <Input id="42" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> <Catalysts> <Catalyst id="40" points="1554 137" /> </Catalysts> <Properties> <displayName>AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="47" reactomeId="5577237" points="1609 172, 1621 138, 1611 98" position="1621 138" lineWidth="1.0"> <Inputs> <Input id="42" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> <Catalysts> <Catalyst id="48" points="1648 137" /> </Catalysts> <Inhibitors> <Inhibitor id="1201" points="1681 253" /> </Inhibitors> <Properties> <displayName>KCNH2:KCNE transport 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points="516 761" /> </Inputs> <Outputs> <Output id="193" stoichiometry="5" points="627 755" /> <Output id="194" points="642 729" /> </Outputs> <Catalysts> <Catalyst id="195" points="570 701" /> </Catalysts> <Properties> <displayName>DMPK phosphorylates PLN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="196" reactomeId="427910" points="573 584, 573 583, 574 583" position="573 583" lineWidth="1.0"> <Inputs> <Input id="197" stoichiometry="2" points="522 542" /> <Input id="202" stoichiometry="2" points="523 613" /> </Inputs> <Outputs> <Output id="198" stoichiometry="2" points="598 521" /> <Output id="199" stoichiometry="2" points="622 622" /> </Outputs> <Catalysts> <Catalyst id="200" points="523 582" /> </Catalysts> <Inhibitors> <Inhibitor id="191" points="478 709" /> <Inhibitor id="974" points="438 538" /> </Inhibitors> <Activators> <Activator id="194" points="656 687" /> <Activator id="306" points="390 325" /> <Activator id="305" points="1132 583" /> </Activators> <Properties> <displayName>ATP2A1-3 transport Ca2+ from cytosol to ER lumen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="215" reactomeId="936897" points="164 467, 163 466, 164 469" position="163 466" lineWidth="1.0"> <Inputs> <Input id="1019" points="203 446" /> <Input id="1020" points="210 420" /> <Input id="1023" stoichiometry="3" points="267 467" /> <Input id="1027" stoichiometry="2" points="99 459" /> </Inputs> <Outputs> <Output id="218" points="208 532" /> <Output id="1021" points="204 500" /> <Output id="1025" stoichiometry="3" points="108 486" /> <Output id="1029" stoichiometry="2" points="276 497" /> </Outputs> <Catalysts> <Catalyst id="220" points="163 380" /> </Catalysts> <Inhibitors> <Inhibitor id="1134" points="110 239, 16 239, 16 389" /> </Inhibitors> <Properties> <displayName>ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+</displayName> </Properties> </org.gk.render.RenderableReaction> 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<displayName>RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="262" reactomeId="169683" points="603 485, 603 450, 603 324" position="603 450" lineWidth="1.0"> <Inputs> <Input id="198" /> </Inputs> <Outputs> <Output id="266" /> </Outputs> <Catalysts> <Catalyst id="263" points="627 450" /> </Catalysts> <Inhibitors> <Inhibitor id="688" points="843 422, 737 350" /> </Inhibitors> <Activators> <Activator id="264" points="568 385" /> </Activators> <Properties> <displayName>IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="267" reactomeId="2089943" points="293 958, 318 918, 293 883" position="318 918" lineWidth="1.0"> <Inputs> <Input id="236" /> </Inputs> <Outputs> <Output id="238" /> </Outputs> <Catalysts> <Catalyst id="268" points="351 918" /> </Catalysts> <Properties> <displayName>TRPC1 translocates calcium from the extracellular region to the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="269" reactomeId="139854" points="1421 408, 1359 408, 1236 356" position="1359 408" lineWidth="1.0"> <Inputs> <Input id="270" /> </Inputs> <Outputs> <Output id="274" /> </Outputs> <Catalysts> <Catalyst id="271" points="1358 438" /> </Catalysts> <Properties> <displayName>IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="408" reactomeId="418309" points="1222 882, 1222 918, 1222 969" position="1222 918" lineWidth="1.0"> <Inputs> <Input id="410" /> </Inputs> <Outputs> <Output id="412" /> </Outputs> <Catalysts> <Catalyst id="409" points="1197 918" /> </Catalysts> <Properties> <displayName>ATP2B1-4 transport cytosolic Ca2+ to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="514" reactomeId="5617178" points="624 918, 624 917, 576 917" position="624 917" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="515" points="671 892" /> <Input id="516" points="666 918" /> </Inputs> <Outputs> <Output id="518" /> </Outputs> <Properties> <displayName>ATP2B4 binds to NOS1, inhibiting it</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="523" reactomeId="5617182" points="447 794, 572 815, 695 793" position="572 815" lineWidth="1.0"> <Inputs> <Input id="191" points="466 737" /> <Input id="192" stoichiometry="5" points="474 785" /> </Inputs> <Outputs> <Output id="194" points="676 729" /> <Output id="193" stoichiometry="5" points="674 777" /> </Outputs> <Catalysts> <Catalyst id="547" points="632 821" /> </Catalysts> <Activators> <Activator id="518" points="530 904" /> </Activators> <Properties> <displayName>PRKACA phosphorylates PLN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="675" reactomeId="5617179" points="774 843, 774 818, 774 795" position="774 818" lineWidth="1.0"> <Inputs> <Input id="680" points="774 864" /> <Input id="681" stoichiometry="2" points="806 855" /> </Inputs> <Outputs> <Output id="678" points="774 757" /> <Output id="679" stoichiometry="2" points="805 784" /> </Outputs> <Catalysts> <Catalyst id="547" points="694 823" /> </Catalysts> <Activators> <Activator id="518" points="553 904" /> </Activators> <Properties> <displayName>PRKACA phosphorylates TNNI3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="685" reactomeId="5226904" points="782 448, 782 448, 815 448" position="782 448" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="686" points="754 424" /> <Input id="263" points="739 448" /> </Inputs> <Outputs> <Output id="688" /> </Outputs> <Properties> <displayName>AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="935" reactomeId="5678261" points="1392 940, 1392 919, 1392 878" position="1392 919" lineWidth="1.0"> <Inputs> <Input id="940" /> </Inputs> <Outputs> <Output id="938" /> </Outputs> <Catalysts> <Catalyst id="936" points="1365 919" /> </Catalysts> <Activators> <Activator id="1297" points="1435 918" /> </Activators> <Properties> <displayName>KCNJ11:ABCC9 transports K+ from extracellular region to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="954" reactomeId="2032800" points="1794 345, 1794 422, 1776 488" position="1794 422" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="972" /> </Inputs> <Outputs> <Output id="955" /> </Outputs> <Activators> <Activator id="956" points="1834 405" /> <Activator id="957" points="1845 442" /> </Activators> <Properties> <displayName>Expression of NPPA (ANF)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="958" reactomeId="5578783" points="1774 516, 1774 545, 1774 580" position="1774 545" lineWidth="1.0"> <Inputs> <Input id="955" /> </Inputs> <Outputs> <Output id="959" points="1868 584" /> <Output id="960" points="1863 563" /> <Output id="961" points="1774 608" /> <Output id="962" points="1882 606" /> </Outputs> <Catalysts> <Catalyst id="963" points="1735 544" /> </Catalysts> <Properties> <displayName>CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="965" reactomeId="6784598" points="1747 687, 1746 688, 1718 711" position="1746 688" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="966" points="1702 664" /> <Input id="961" points="1770 636" /> </Inputs> <Outputs> <Output id="967" /> </Outputs> <Properties> <displayName>NPPA(124-151) binds NPR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="968" reactomeId="5692408" points="1634 952, 1633 952, 1667 932" position="1633 952" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="969" points="1611 972" /> <Input id="970" points="1610 932" /> </Inputs> <Outputs> <Output id="971" /> </Outputs> <Properties> <displayName>NPR2 binds NPPC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="991" reactomeId="9613600" points="1584 190, 1478 190, 1406 137, 1467 78, 1587 79" position="1406 137" lineWidth="1.0"> <Inputs> <Input id="42" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> <Catalysts> <Catalyst id="992" points="1373 137" /> </Catalysts> <Inhibitors> <Inhibitor id="1189" points="1258 173, 1336 205" /> </Inhibitors> <Properties> <displayName>KCNA5 tetramers transport K+ from cytosol to extracellular region</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1132" reactomeId="9684068" points="163 313, 162 313, 162 269" position="162 313" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1133" points="138 313" /> <Input id="220" points="163 352" /> </Inputs> <Outputs> <Output id="1134" /> </Outputs> <Properties> <displayName>ATP1A:ATP1B:FXYD binds cardiac glycosides</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1166" reactomeId="9612559" points="292 113, 294 113, 251 125" position="294 113" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="25" points="316 115" /> <Input id="1167" points="292 89" /> </Inputs> <Outputs> <Output id="1168" /> </Outputs> <Properties> <displayName>Class I antiarrhythmics bind SCNAs:SNCBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1175" reactomeId="9614031" points="668 72, 668 71, 638 107" position="668 71" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1176" points="668 46" /> <Input id="30" points="739 124" /> </Inputs> <Outputs> <Output id="1177" /> </Outputs> <Properties> <displayName>Class IV antihypertensives bind LTCC multimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1187" reactomeId="9613570" points="1291 88, 1292 87, 1242 116" position="1292 87" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="992" points="1321 117" /> <Input id="1188" points="1290 64" /> </Inputs> <Outputs> <Output id="1189" /> </Outputs> <Properties> <displayName>Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1199" reactomeId="9613264" points="1694 203, 1694 204, 1694 253" position="1694 204" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1200" points="1745 194" /> <Input id="48" points="1694 150" /> </Inputs> <Outputs> <Output id="1201" /> </Outputs> <Properties> <displayName>Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1295" reactomeId="9691566" points="1405 1008, 1405 1008, 1474 939" position="1405 1008" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1296" points="1355 1025" /> <Input id="936" points="1324 934" /> </Inputs> <Outputs> <Output id="1297" /> </Outputs> <Properties> <displayName>KCNJ11:ABCC9 binds nicorandil</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1339" reactomeId="9727387" points="1774 765, 1774 796, 1841 796" position="1774 796" lineWidth="1.0"> <Inputs> <Input id="1340" points="1805 735" /> <Input id="961" points="1774 636" /> </Inputs> <Outputs> <Output id="1352" points="1915 823" /> <Output id="1353" points="1893 796" /> </Outputs> <Catalysts> <Catalyst id="1341" points="1733 793" /> </Catalysts> <Properties> <displayName>MME:Zn2+ hydrolyses NPPA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1354" reactomeId="9727607" points="1621 813, 1621 813, 1661 836" position="1621 813" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1341" points="1657 801" /> <Input id="1355" points="1585 813" /> </Inputs> <Outputs> <Output id="1356" /> </Outputs> <Properties> <displayName>MME:Zn2+ binds sacubitrilat</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1442" reactomeId="9727567" points="1542 676, 1542 720, 1542 742" position="1542 720" lineWidth="1.0"> <Inputs> <Input id="1443" points="1542 634" /> <Input id="1450" points="1527 665" /> </Inputs> <Outputs> <Output id="1456" points="1520 754" /> <Output id="1355" points="1542 795" /> </Outputs> <Catalysts> <Catalyst id="1444" points="1462 720" /> </Catalysts> <Properties> <displayName>CES1 hydrolyses sacubitril to sacubitrilat</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Cardiac conduction (5576889)
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