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Details on Person UniProt:Q9P2T1 GMPR2
Class:Id
ReferenceGeneProduct:55762
_chainChangeLog
chain:1-348 added on Fri February 6 2015
_displayName
UniProt:Q9P2T1 GMPR2
_timestamp
2025-02-21 18:47:11
chain
chain:1-348
checksum
E7812A754C433E51
comment
FUNCTION Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).CATALYTIC ACTIVITY IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)SUBUNIT Homotetramer.INTERACTION Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.SIMILARITY Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
