Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P36959 GMPR
| Class:Id | ReferenceGeneProduct:55760 |
|---|---|
| _chainChangeLog | chain:1-345 added on Sat February 7 2015 |
| _displayName | UniProt:P36959 GMPR |
| _timestamp | 2025-02-21 18:47:10 |
| chain | chain:1-345 |
| checksum | 217E1A5A599CA510 |
| comment | FUNCTION Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.CATALYTIC ACTIVITY IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)SUBUNIT Homotetramer.INTERACTION At least two different alleles are known.SIMILARITY Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.CAUTION The N-terminus was initially (PubMed:2758468) thought to be fused with glucose-6-phosphate-dehydrogenase (G6PD) protein in vivo. However, PubMed:2570640 showed that it encodes a GMP reductase, and PubMed:1694726 showed that the chimeric protein is an artifact. |
| description | recommendedName: fullName evidence="1"GMP reductase 1 shortName evidence="1"GMPR 1 ecNumber evidence="1"1.7.1.7 alternativeName: fullName evidence="1"Guanosine 5'-monophosphate oxidoreductase 1 shortName evidence="1"Guanosine monophosphate reductase 1 |
| geneName | GMPR GMPR1 |
| identifier | P36959 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Metal-binding NADP Oxidoreductase Potassium Proteomics identification Purine metabolism Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | GMPR |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995449] ENSEMBL:ENSG00000137198 GMPR [Homo sapiens] |
| secondaryIdentifier | GMPR1_HUMAN Q96HQ6 |
| sequenceLength | 345 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:514605] GMPR [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P36959 GMPR (55760)
