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Details on Person UniProt:P01215 CGA
| Class:Id | ReferenceGeneProduct:55672 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Sat February 7 2015;chain:25-116 added on Sat February 7 2015 |
| _displayName | UniProt:P01215 CGA |
| _timestamp | 2024-11-03 20:05:30 |
| chain | signal peptide:1-24 chain:25-116 |
| checksum | F0623CD8CC90CFCD |
| comment | FUNCTION Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.SUBUNIT Heterodimer. The active hormones thyrotropin, lutropin, follitropin and choriogonadotropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin, FSHB for follitropin and choriogonadotropin subunit beta/CGB for choriogonadotropin.INTERACTION Belongs to the glycoprotein hormones subunit alpha family.ONLINE INFORMATION Proteic grace - Issue 77 of December 2006 |
| description | recommendedName: Glycoprotein hormones alpha chain alternativeName: Anterior pituitary glycoprotein hormones common subunit alpha alternativeName: Choriogonadotropin alpha chain alternativeName: Chorionic gonadotrophin subunit alpha shortName: CG-alpha alternativeName: Follicle-stimulating hormone alpha chain shortName: FSH-alpha alternativeName: Follitropin alpha chain alternativeName: Luteinizing hormone alpha chain shortName: LSH-alpha alternativeName: Lutropin alpha chain alternativeName: Thyroid-stimulating hormone alpha chain shortName: TSH-alpha alternativeName: Thyrotropin alpha chain |
| geneName | CGA |
| identifier | P01215 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Hormone Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CGA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8864409] ENSEMBL:ENSG00000135346 CGA [Homo sapiens] |
| secondaryIdentifier | GLHA_HUMAN |
| sequenceLength | 116 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:378967] CGA [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6786359] S-glyco-CGA [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6793928] CGA [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:6793933] S-glyco-CGA [Golgi lumen] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:6786343] glycosylated residue (4-O-sulfo-N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl group) at 76 [GroupModifiedResidue:6786347] glycosylated residue (4-O-sulfo-N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl group) at 102 [GroupModifiedResidue:6786391] glycosylated residue (N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl group) at 76 [GroupModifiedResidue:6786393] glycosylated residue (N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl group) at 102 |
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No pathways have been reviewed or authored by UniProt:P01215 CGA (55672)
