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Details on Person UniProt:P15586 GNS
Class:Id
ReferenceGeneProduct:55660
_chainChangeLog
signal peptide:1-36 added on Sat February 7 2015;chain:37-552 added on Sat February 7 2015
_displayName
UniProt:P15586 GNS
_timestamp
2025-05-21 21:55:41
chain
signal peptide:1-36 chain:37-552
checksum
85094043F6E64468
comment
FUNCTION Hydrolyzes 6-sulfate groups in N-acetyl-d-glucosaminide units of heparin sulfate and keratan sulfate.CATALYTIC ACTIVITY Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.COFACTOR Binds 1 Ca(2+) ion per subunit.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 4.8.INTERACTION The form A (78 kDa) is processed by internal peptidase cleavage to a 32 kDa N-terminal species (form B) and a 48 kDa C-terminal species.PTM The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the sulfatase family.
Alternative splicing Calcium Direct protein sequencing Disease variant Glycoprotein Hydrolase Lysosome Metal-binding Mucopolysaccharidosis Phosphoprotein Proteomics identification Reference proteome Signal
