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Details on Person UniProt:P06396 GSN
| Class:Id | ReferenceGeneProduct:55564 |
|---|---|
| _chainChangeLog | signal peptide:1-27 added on Fri February 6 2015;chain:28-782 added on Fri February 6 2015 |
| _displayName | UniProt:P06396 GSN |
| _timestamp | 2024-11-03 19:51:19 |
| chain | signal peptide:1-27 chain:28-782 |
| checksum | 8CEBC52257A160F7 |
| comment | FUNCTION Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (PubMed:19666512). Plays a role in ciliogenesis (PubMed:20393563).SUBUNIT Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X. Interacts with the inactive form of EIF2AK2/PKR (By similarity). Interacts with FLII (By similarity).INTERACTION Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.DOMAIN Comprises six structurally related gelsolin-like (G1-G6) domains, that, in a calcium-free environment, are packed together to form a compact globular structure in which the putative actin-binding sequences are not sufficiently exposed to enable binding to occur (PubMed:19666512). Binding calcium may release the connections that join the N- and C-terminal halves of gelsolin, enabling each half to bind actin relatively independently (PubMed:12460571, PubMed:19666512). G1 and G4 bind two Ca(2+) in a type I and in a type II manner (PubMed:12460571, PubMed:19666512). G2, G3, G5 and G6 bind only one Ca(2+) in a type II manner (PubMed:12460571, PubMed:19666512). Type I Ca(2+) binding sites are shared between actin and gelsolin-like repeats G1 and G4 (PubMed:12460571, PubMed:19666512). Type I binding governs the strength of interactions between gelsolin and actin by direct participation at the binding interface (PubMed:12460571, PubMed:19666512). Ca(2+) binding to G2 and G6 disrupts the interactions between G2 and G6, releases the C-terminal tail, and induces large interdomain rearrangements that result in the exposure of the F-actin-binding site on G2 and contributes to the activation of gelsolin (PubMed:12460571, PubMed:19666512). Binding to phosphoinositides may inhibit the severing and capping properties of gelsolin (Probable).PTM Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the villin/gelsolin family.ONLINE INFORMATION Gelsolin entry |
| description | recommendedName: Gelsolin alternativeName: AGEL alternativeName: Actin-depolymerizing factor shortName: ADF alternativeName: Brevin |
| geneName | GSN |
| identifier | P06396 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Actin capping Actin-binding Alternative initiation Alternative splicing Amyloid Amyloidosis Calcium Cilium biogenesis/degradation Corneal dystrophy Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Disulfide bond Metal-binding Phosphoprotein Proteomics identification Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GSN |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957887] ENSEMBL:ENSG00000148180 GSN [Homo sapiens] |
| secondaryIdentifier | GELS_HUMAN A2A418 A8MUD1 A8MYN7 B7Z373 B7Z5V1 F5H1A8 Q5T0I2 Q8WVV7 |
| sequenceLength | 782 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:230411] UniProt:P06396-2 GSN [Homo sapiens] [ReferenceIsoform:402502] UniProt:P06396-1 GSN [Homo sapiens] [ReferenceIsoform:8971947] UniProt:P06396-3 GSN [Homo sapiens] [ReferenceIsoform:8971948] UniProt:P06396-4 GSN [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201618] GSN(28-403) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:350272] GSN(404-782) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:350275] GSN [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:976940] GSN(200-270) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6801465] GSN [ficolin-1-rich granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801486] GSN [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801545] GSN [extracellular exosome] [Homo sapiens] [EntityWithAccessionedSequence:6806510] GSN [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P06396 GSN (55564)
