Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P23434 GCSH
| Class:Id | ReferenceGeneProduct:55510 |
|---|---|
| _chainChangeLog | transit peptide:1-48 added on Sat February 7 2015;chain:49-173 added on Sat February 7 2015 |
| _displayName | UniProt:P23434 GCSH |
| _timestamp | 2026-02-20 21:39:48 |
| chain | transit peptide:1-48 chain:49-173 |
| checksum | 3CC5D09D59C1243D |
| comment | FUNCTION The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST) (PubMed:36190515).COFACTOR Binds 1 lipoyl cofactor covalently.SUBUNIT Interacts with GLDC (By similarity). The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH).INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the GcvH family. |
| description | recommendedName: fullName evidence="9"Glycine cleavage system H protein, mitochondrial alternativeName: Lipoic acid-containing protein |
| geneName | GCSH |
| identifier | P23434 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Disease variant Lipoyl Mitochondrion Neurodegeneration Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | GCSH |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999503] ENSEMBL:ENSG00000140905 GCSH [Homo sapiens] |
| secondaryIdentifier | GCSH_HUMAN Q9H1E9 |
| sequenceLength | 173 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5693951] GCSH [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:5694601] lipoyl-K107-GCSH [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:6792571] lipo-107-GCSH [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:6793586] octanoyl-K107-GCSH [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:6793611] Lipo-K107-GCSH [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9930732] AmMeLipo-K107-GCSH [mitochondrial matrix] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:5694589] N6-lipoyl-L-lysine at 107 [ModifiedResidue:6792576] N6-lipoyl-L-lysine at 107 [ModifiedResidue:6793588] N6-octanoyl-L-lysine at 107 [GroupModifiedResidue:9930735] N6-lipoyl-L-lysine (N(6)-((R)-S(8)-ammoniomethyldihydrolipoyl)-L-lysine(1+) residue) at 173 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P23434 GCSH (55510)
