Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O95843 GUCA1C
| Class:Id | ReferenceGeneProduct:55482 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-209 added on Sat February 7 2015;initiator methionine:1 for 55482 removed on Fri Nov 03 2023;initiator methionine: for 55482 added on Fri Nov 03 2023;initiator methionine: for 55482 removed on Fri Aug 15 2025;initiator methionine:1 for 55482 added on Fri Aug 15 2025 |
| _displayName | UniProt:O95843 GUCA1C |
| _timestamp | 2026-02-20 23:06:02 |
| chain | initiator methionine:1 chain:2-209 |
| checksum | A407E7D4AEBBAED3 |
| comment | FUNCTION Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.INTERACTION Retina.DOMAIN Binds three calcium ions (via EF-hand 2, 3 and 4). |
| description | recommendedName: Guanylyl cyclase-activating protein 3 shortName: GCAP 3 alternativeName: Guanylate cyclase activator 1C |
| geneName | GUCA1C GCAP3 |
| identifier | O95843 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium Lipoprotein Metal-binding Myristate Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | GUCA1C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997736] ENSEMBL:ENSG00000138472 GUCA1C [Homo sapiens] |
| secondaryIdentifier | GUC1C_HUMAN O95844 Q9UNM0 |
| sequenceLength | 209 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:147824] UniProt:O95843-2 GUCA1C [Homo sapiens] [ReferenceIsoform:402186] UniProt:O95843-1 GUCA1C [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:2586743] GUCA1C [photoreceptor disc membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O95843 GUCA1C (55482)
