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Details on Person UniProt:Q9UMX6 GUCA1B
| Class:Id | ReferenceGeneProduct:55480 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-200 added on Sat February 7 2015;initiator methionine:1 for 55480 removed on Fri Nov 03 2023;initiator methionine: for 55480 added on Fri Nov 03 2023;initiator methionine: for 55480 removed on Fri Aug 15 2025;initiator methionine:1 for 55480 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9UMX6 GUCA1B |
| _timestamp | 2025-08-15 21:07:35 |
| chain | initiator methionine:1 chain:2-200 |
| checksum | 79B898868BA35768 |
| comment | FUNCTION Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity).INTERACTION Subcellular location is not affected by light or dark conditions.TISSUE SPECIFICITY In the retina, it is expressed in cone and rod photoreceptor cells.PTM The N-terminus is blocked.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Binds three calcium ions. |
| description | recommendedName: Guanylyl cyclase-activating protein 2 shortName: GCAP 2 alternativeName: Guanylate cyclase activator 1B |
| geneName | GUCA1B GCAP2 |
| identifier | Q9UMX6 |
| isSequenceChanged | FALSE |
| keyword | Calcium Cell membrane Cell projection Disease variant Lipoprotein Membrane Metal-binding Myristate Proteomics identification Reference proteome Repeat Retinitis pigmentosa Sensory transduction Vision |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GUCA1B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987864] ENSEMBL:ENSG00000112599 GUCA1B [Homo sapiens] |
| secondaryIdentifier | GUC1B_HUMAN Q9NU15 |
| sequenceLength | 200 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:55479] GUCA1B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2586741] GUCA1B [photoreceptor disc membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UMX6 GUCA1B (55480)
