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Details on Person UniProt:P9WHS1 mec
| Class:Id | ReferenceGeneProduct:5545402 |
|---|---|
| _chainChangeLog | chain:1-146 added on Fri February 6 2015 |
| _displayName | UniProt:P9WHS1 mec |
| _timestamp | 2025-02-21 19:50:00 |
| chain | chain:1-146 |
| checksum | 333945ED84CF2D5E |
| comment | FUNCTION Protease that hydrolyzes the covalent CysO-cysteine adduct synthesized by CysM to release L-cysteine and regenerate CysO.CATALYTIC ACTIVITY [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O = [CysO sulfur-carrier protein]-C-terminal Gly-Gly + L-cysteine + H(+)COFACTOR Inhibited by EDTA in vitro.PATHWAY Amino-acid biosynthesis; L-cysteine biosynthesis.INDUCTION Up-regulated under oxidative stress conditions.DISRUPTION PHENOTYPE Strains lacking this gene are shown to be attenuated in macrophages.SIMILARITY Belongs to the peptidase M67A family. |
| created | [InstanceEdit:5545400] D'Eustachio, Peter, 2014-05-20 |
| description | recommendedName: CysO-cysteine peptidase ecNumber evidence="4"3.13.1.6 alternativeName: Metallocarboxypeptidase Mec |
| geneName | mec mec+ Rv1334 MTCY130.19 |
| identifier | P9WHS1 |
| isSequenceChanged | FALSE |
| keyword | Amino-acid biosynthesis Cysteine biosynthesis Hydrolase Metal-binding Metalloprotease Protease Reference proteome Zinc |
| modified | [InstanceEdit:5545408] D'Eustachio, Peter, 2014-05-20 [InstanceEdit:5545413] D'Eustachio, Peter, 2014-05-20 [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | mec |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MEC_MYCTU L0T6J9 P64813 Q10645 |
| sequenceLength | 146 |
| species | [Species:5545372] Mycobacterium tuberculosis H37Rv |
| (referenceEntity) | [EntityWithAccessionedSequence:936660] Mec+ [cytosol] [Mycobacterium tuberculosis] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P9WHS1 mec (5545402)
