Query author contributions in Reactome
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Details on Person UniProt:P9WJ03 sir
| Class:Id | ReferenceGeneProduct:5545376 |
|---|---|
| _chainChangeLog | chain:1-555 added on Fri February 6 2015 |
| _displayName | UniProt:P9WJ03 sir |
| _timestamp | 2025-02-21 19:43:09 |
| chain | chain:1-555 |
| checksum | 68925CA37C131BC3 |
| comment | FUNCTION Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.CATALYTIC ACTIVITY hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] + 3 H2O = sulfite + 6 reduced [2Fe-2S]-[ferredoxin] + 7 H(+)COFACTOR Binds 1 siroheme per subunit.COFACTOR Binds 1 [4Fe-4S] cluster per subunit.SUBUNIT Monomer.MISCELLANEOUS Was identified as a high-confidence drug target.SIMILARITY Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:5545375] D'Eustachio, Peter, 2014-05-20 |
| description | recommendedName: Sulfite reductase [ferredoxin] ecNumber evidence="2"1.8.7.1 |
| geneName | sir nirA Rv2391 |
| identifier | P9WJ03 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure 4Fe-4S Heme Iron Iron-sulfur Metal-binding Oxidoreductase Reference proteome Thioether bond |
| modified | [InstanceEdit:5545385] D'Eustachio, Peter, 2014-05-20 [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | sir |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SIR_MYCTU L0T9H3 P71753 Q7D781 |
| sequenceLength | 555 |
| species | [Species:5545372] Mycobacterium tuberculosis H37Rv |
| (referenceEntity) | [EntityWithAccessionedSequence:936705] Sir [cytosol] [Mycobacterium tuberculosis] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P9WJ03 sir (5545376)
