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Details on Person UniProt:O60262 GNG7
| Class:Id | ReferenceGeneProduct:55414 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-65 added on Fri February 6 2015;propeptide:66-68 added on Fri February 6 2015;initiator methionine:1 for 55414 removed on Fri Nov 03 2023;initiator methionine: for 55414 added on Fri Nov 03 2023;initiator methionine: for 55414 removed on Fri Aug 15 2025;initiator methionine:1 for 55414 added on Fri Aug 15 2025 |
| _displayName | UniProt:O60262 GNG7 |
| _timestamp | 2025-08-15 21:53:00 |
| chain | initiator methionine:1 chain:2-65 propeptide:66-68 |
| checksum | 704133C7BEC7FD72 |
| comment | FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilization of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma.INTERACTION Expressed in a variety of tissues. Down-regulated in pancreatic and esophageal cancer.SIMILARITY Belongs to the G protein gamma family. |
| description | recommendedName: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 |
| geneName | GNG7 GNGT7 |
| identifier | O60262 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cell membrane Lipoprotein Membrane Methylation Prenylation Proteomics identification Reference proteome Transducer |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GNG7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990710] ENSEMBL:ENSG00000176533 GNG7 [Homo sapiens] |
| secondaryIdentifier | GBG7_HUMAN B2R496 |
| sequenceLength | 68 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:164325] GNG7 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O60262 GNG7 (55414)
