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Details on Person UniProt:P62871 GNB1
| Class:Id | ReferenceGeneProduct:55378 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-340 added on Fri February 6 2015;initiator methionine:1 for 55378 removed on Fri Nov 03 2023;initiator methionine: for 55378 added on Fri Nov 03 2023;initiator methionine: for 55378 removed on Fri Aug 15 2025;initiator methionine:1 for 55378 added on Fri Aug 15 2025 |
| _displayName | UniProt:P62871 GNB1 |
| _timestamp | 2026-02-20 21:59:26 |
| chain | initiator methionine:1 chain:2-340 |
| checksum | 896CBD32D2686598 |
| comment | FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma (PubMed:8521505). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (PubMed:12764189). The heterodimer formed by GNB1 and GNG2 interacts with the ghrelin receptor GHSR (By similarity). Forms a complex with GNAO1 and GNG3 (By similarity). Interacts with ARHGEF18 and RASD2 (By similarity). Forms complexes with TAS2R14 and G-proteins; these complexes play a role in the perception of bitterness (By similarity). Component of the TAS2R14-GNAI1 complex, consisting of TAS2R14, GNAI1, GNB1 and GNG2 (By similarity). Component of the TAS2R14-GNAT3 complex, consisting of TAS2R14, GNAT3, GNB1 and GNG2 (By similarity). Component of the TAS2R14-GNAS2 complex, consisting of TAS2R14, GNAS2, GNB1 and GNG2 (By similarity). Component of the ADORA1-GNAI2 complex, consisting of ADORA1, GNAI2, GNB1 and GNG2 (By similarity). Component of the CNR1-GNAI2 complex, consisting of CNR1, GNAI2, GNB1 and GNG2 (By similarity). Component of the FPR2-GNAI2 complex, consisting of FPR2, GNAI2, GNB1 and GNG2 (By similarity). Interacts with MC1R, the interaction is important for coupling of MC1R to G protein (By similarity). Component of a complex composed of FPR1 or FPR2 receptor and G(i) protein subunits GNAI1, GNB1 and GNG2; this complex is involved in innate recognition of N-formyl-methionyl peptides derived from invading microbes and host mitochondria as pathogen- and damage-associated molecular patterns (PAMPs and DAMPs).INTERACTION Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.SIMILARITY Belongs to the WD repeat G protein beta family. |
| description | recommendedName: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 alternativeName: Transducin beta chain 1 |
| geneName | GNB1 |
| identifier | P62871 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Phosphoprotein Reference proteome Repeat Transducer WD repeat |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | GNB1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GBB1_BOVIN P04697 P04901 Q3MHF1 |
| sequenceLength | 340 |
| species | [Species:48898] Bos taurus |
| (referenceEntity) | [EntityWithAccessionedSequence:55377] Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1 [Bos taurus] [EntityWithAccessionedSequence:2530483] Gnb1 [photoreceptor disc membrane] [Bos taurus] |
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No pathways have been reviewed or authored by UniProt:P62871 GNB1 (55378)
