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Details on Person UniProt:Q14344 GNA13
| Class:Id | ReferenceGeneProduct:55358 |
|---|---|
| _chainChangeLog | chain:1-377 added on Sat February 7 2015 |
| _displayName | UniProt:Q14344 GNA13 |
| _timestamp | 2025-02-21 19:38:14 |
| chain | chain:1-377 |
| checksum | 929B7B6473C54F2E |
| comment | FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16705036, PubMed:16787920, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:12515866, PubMed:15240885). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16705036, PubMed:16787920, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in a process independent from Rho activation (PubMed:11976333). In lymphoid follicles, transmits P2RY8- and S1PR2-dependent signals that lead to inhibition of germinal center (GC) B cell growth and migration outside the GC niche.SUBUNIT G proteins are composed of 3 units; alpha, beta and gamma (PubMed:12399457). The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts with UBXD5 (PubMed:16202387). Interacts with HAX1 (PubMed:15339924). Interacts (in GTP-bound form) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RGS22 (PubMed:18703424). Interacts (in GTP-bound form) with ARHGEF1 (PubMed:10747909). Interacts (in GTP-bound form) with ARHGEF11 (via RGS domain) (PubMed:10026210). Interacts (in GTP-bound form) with ARHGEF12 (via RGS domain) (PubMed:11094164). Interacts with CTNND1 (PubMed:15240885). Interacts with GASL2L2 (PubMed:23994616). Interacts with GPR35 (PubMed:36543774). Interacts with GPR174 (By similarity).INTERACTION Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages (PubMed:18703424). In round spermatids, also present in the nuclei (PubMed:18703424).ALTERNATIVE PRODUCTS Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level).PTM Palmitoylation is critical for proper membrane localization and signaling.PTM Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation.SIMILARITY Belongs to the G-alpha family. G(12) subfamily. |
| description | recommendedName: Guanine nucleotide-binding protein subunit alpha-13 shortName: G alpha-13 shortName: G-protein subunit alpha-13 |
| geneName | GNA13 |
| identifier | Q14344 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Cytoplasm GTP-binding Lipoprotein Magnesium Membrane Metal-binding Nucleotide-binding Nucleus Palmitate Phosphoprotein Proteomics identification Reference proteome Transducer |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | GNA13 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996592] ENSEMBL:ENSG00000120063 GNA13 [Homo sapiens] |
| secondaryIdentifier | GNA13_HUMAN B2R977 B7Z7R0 F5H1G8 Q8TD70 |
| sequenceLength | 377 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977429] UniProt:Q14344-1 GNA13 [Homo sapiens] [ReferenceIsoform:8977430] UniProt:Q14344-2 GNA13 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:167451] GNA13 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q14344 GNA13 (55358)
