Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q03113 GNA12
| Class:Id | ReferenceGeneProduct:55356 |
|---|---|
| _chainChangeLog | chain:1-381 added on Fri February 6 2015 |
| _displayName | UniProt:Q03113 GNA12 |
| _timestamp | 2024-11-03 20:10:04 |
| chain | chain:1-381 |
| checksum | 04C3F12B29255F89 |
| comment | FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:12515866, PubMed:15240885, PubMed:15525651, PubMed:16705036, PubMed:16787920, PubMed:17565996, PubMed:22609986, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:12515866, PubMed:15240885, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production (PubMed:16705036, PubMed:16787920, PubMed:23762476, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).SUBUNIT G proteins are composed of 3 units; alpha, beta and gamma (PubMed:10026210). The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts with UBXD5 (PubMed:16202387). Interacts (in GTP-bound form) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RGS22 (PubMed:18703424). Interacts (via N-terminus) with NAPA; the interaction promotes CDH5 localization to plasma membrane (PubMed:15980433). Interacts with CTNND1 (via N-terminus); the interaction regulates CDH1-mediated cell-cell adhesion (PubMed:15240885). Interacts with PPP2R1A; the interaction promotes protein phosphatase 2A activation causing dephosphorylation of MAPT (PubMed:15525651). Interacts (in GTP-bound form) with ARHGEF1 (By similarity). Interacts (in GTP-bound form) with ARHGEF11 (via RGS domain) (PubMed:10026210). Interacts (in GTP-bound form) with ARHGEF12 (via RGS domain) (PubMed:11094164).SUBCELLULAR LOCATION CDH1 enhances cell membrane localization.ALTERNATIVE PRODUCTS Belongs to the G-alpha family. G(12) subfamily. |
| description | recommendedName: Guanine nucleotide-binding protein subunit alpha-12 shortName: G alpha-12 shortName: G-protein subunit alpha-12 |
| geneName | GNA12 |
| identifier | Q03113 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative initiation Cell membrane Cytoplasm GTP-binding Lipoprotein Magnesium Membrane Metal-binding Nucleotide-binding Palmitate Phosphoprotein Proteomics identification Reference proteome Transducer |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GNA12 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003550] ENSEMBL:ENSG00000146535 GNA12 [Homo sapiens] |
| secondaryIdentifier | GNA12_HUMAN A4D204 B3KXS2 B7Z3F7 Q2T9L1 Q5PPR5 Q86UM8 Q8TD71 Q9UDU9 |
| sequenceLength | 381 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8966105] UniProt:Q03113-1 GNA12 [Homo sapiens] [ReferenceIsoform:8966106] UniProt:Q03113-2 GNA12 [Homo sapiens] [ReferenceIsoform:8966107] UniProt:Q03113-3 GNA12 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:55355] GNA12 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:391978] GNA12 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q03113 GNA12 (55356)
