Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O43903 GAS2
| Class:Id | ReferenceGeneProduct:55326 |
|---|---|
| _chainChangeLog | chain:1-313 added on Sat February 7 2015 |
| _displayName | UniProt:O43903 GAS2 |
| _timestamp | 2025-02-21 19:48:10 |
| chain | chain:1-313 |
| checksum | A5FBA611A0C8B36F |
| comment | FUNCTION Required to maintain microtubule bundles in inner ear supporting cells, affording them with mechanical stiffness to transmit sound energy through the cochlea.INTERACTION Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles (By similarity). Colocalizes with detyrosinated alpha-tubulin along the length of microtubule bundles in inner and outer pillar cells (By similarity).ALTERNATIVE PRODUCTS Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.DEVELOPMENTAL STAGE Specifically expressed at growth arrest.PTM Cleaved, during apoptosis, on a specific aspartic residue by caspases.PTM Phosphorylated on serine residues during the G0-G1 transition phase.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the GAS2 family. |
| description | recommendedName: Growth arrest-specific protein 2 shortName: GAS-2 |
| geneName | GAS2 |
| identifier | O43903 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Apoptosis Cell cycle Cell shape Cytoplasm Cytoskeleton Deafness Growth arrest Membrane Non-syndromic deafness Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | GAS2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997173] ENSEMBL:ENSG00000148935 GAS2 [Homo sapiens] |
| secondaryIdentifier | GAS2_HUMAN B2R9C8 D3DQZ0 Q6ICV8 Q7Z3X8 |
| sequenceLength | 313 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8967421] UniProt:O43903-1 GAS2 [Homo sapiens] [ReferenceIsoform:8967422] UniProt:O43903-2 GAS2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201614] GAS2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:202833] GAS2(1-279) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:202887] GAS2(280-313) [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O43903 GAS2 (55326)
