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Details on Person UniProt:P34903 GABRA3
| Class:Id | ReferenceGeneProduct:55248 |
|---|---|
| _chainChangeLog | signal peptide:1-28 added on Sat February 7 2015;chain:29-492 added on Sat February 7 2015 |
| _displayName | UniProt:P34903 GABRA3 |
| _timestamp | 2025-08-15 22:08:10 |
| chain | signal peptide:1-28 chain:29-492 |
| checksum | 23A7390C9822691F |
| comment | FUNCTION Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:29053855). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:16412217, PubMed:29053855). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:16412217, PubMed:29053855).CATALYTIC ACTIVITY chloride(in) = chloride(out)ACTIVITY REGULATION Potentiated by etomidate, propofol, pregnanolone and flurazepam.SUBUNIT Heteropentamer, formed by a combination of alpha (GABRA1-6), beta (GABRB1-3), gamma (GABRG1-3), delta (GABRD), epsilon (GABRE), rho (GABRR1-3), pi (GABRP) and theta (GABRQ) chains, each subunit exhibiting distinct physiological and pharmacological properties (PubMed:16412217). Binds UBQLN1 (By similarity). Interacts with GPHN (PubMed:26613940).SUBCELLULAR LOCATION GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily.ONLINE INFORMATION Forbidden fruit - Issue 56 of March 2005 |
| description | recommendedName: fullName evidence="2"Gamma-aminobutyric acid receptor subunit alpha-3 alternativeName: fullName evidence="2"GABA(A) receptor subunit alpha-3 shortName: GABAAR subunit alpha-3 |
| geneName | GABRA3 |
| identifier | P34903 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Chloride Chloride channel Disease variant Disulfide bond Epilepsy Glycoprotein Ion channel Ion transport Ligand-gated ion channel Membrane Phosphoprotein Postsynaptic cell membrane Proteomics identification Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GABRA3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992469] ENSEMBL:ENSG00000011677 GABRA3 [Homo sapiens] |
| secondaryIdentifier | GBRA3_HUMAN Q8TAF9 |
| sequenceLength | 492 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:975289] GABRA3 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P34903 GABRA3 (55248)
