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Details on Person UniProt:P35575 G6PC1
| Class:Id | ReferenceGeneProduct:55228 |
|---|---|
| _chainChangeLog | chain:1-357 added on Sat February 7 2015 |
| _displayName | UniProt:P35575 G6PC1 |
| _timestamp | 2025-08-15 21:45:20 |
| chain | chain:1-357 |
| checksum | 2FEA1C78928A9919 |
| comment | FUNCTION Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.CATALYTIC ACTIVITY D-glucose 6-phosphate + H2O = D-glucose + phosphatePATHWAY Carbohydrate biosynthesis; gluconeogenesis.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the glucose-6-phosphatase family.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: fullName evidence="36"Glucose-6-phosphatase catalytic subunit 1 ecNumber evidence="9 12 16 25"3.1.3.9 alternativeName: Glucose-6-phosphatase shortName: G-6-Pase shortName: G6Pase alternativeName: Glucose-6-phosphatase alpha shortName: G6Pase-alpha |
| geneName | G6PC1 G6PC G6PT |
| identifier | P35575 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Disease variant Endoplasmic reticulum Gluconeogenesis Glycogen storage disease Glycoprotein Hydrolase Membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | G6PC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990134] ENSEMBL:ENSG00000131482 G6PC1 [Homo sapiens] |
| secondaryIdentifier | G6PC1_HUMAN A1L4C0 B4E1C3 K7EL82 |
| sequenceLength | 357 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968795] UniProt:P35575-1 G6PC1 [Homo sapiens] [ReferenceIsoform:8968796] UniProt:P35575-2 G6PC1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:71823] G6PC [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:3274529] G6PC R83C [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:3274553] G6PC H119L [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:3274556] G6PC R170Q [endoplasmic reticulum membrane] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:3274532] L-arginine 170 replaced with L-glutamine [ReplacedResidue:3274547] L-histidine 119 replaced with L-leucine [ReplacedResidue:3274548] L-arginine 83 replaced with L-cysteine |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P35575 G6PC1 (55228)
