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Details on Person UniProt:O14556 GAPDHS
| Class:Id | ReferenceGeneProduct:55214 |
|---|---|
| _chainChangeLog | chain:1-408 added on Fri February 6 2015 |
| _displayName | UniProt:O14556 GAPDHS |
| _timestamp | 2026-02-20 22:21:38 |
| chain | chain:1-408 |
| checksum | 301F71C768CD95D8 |
| comment | FUNCTION Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis (By similarity). May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).CATALYTIC ACTIVITY D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)PATHWAY Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.SUBUNIT Homotetramer. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation.INTERACTION Testis specific.DOMAIN The testis-specific N-terminal extension mediates tight association with the cytoskeletal fibrous sheath of the spermatozoa flagellum, possibly via interchain disulfide-bonding of Cys-21 with sheath components.SIMILARITY Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. |
| description | recommendedName: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific ecNumber: 1.2.1.12 alternativeName: Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2 shortName: GAPDH-2 alternativeName: Spermatogenic glyceraldehyde-3-phosphate dehydrogenase |
| geneName | GAPDHS GAPD2 GAPDH2 GAPDS HSD-35 HSD35 |
| identifier | O14556 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Glycolysis NAD Oxidoreductase Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | GAPDHS |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994818] ENSEMBL:ENSG00000105679 GAPDHS [Homo sapiens] |
| secondaryIdentifier | G3PT_HUMAN B2RC82 O60823 Q6JTT9 Q9HCU6 |
| sequenceLength | 408 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:372873] GAPDHS [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6813805] Unfolded GAPDHS [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O14556 GAPDHS (55214)
