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Details on Person UniProt:Q9H461 FZD8
| Class:Id | ReferenceGeneProduct:55180 |
|---|---|
| _chainChangeLog | signal peptide:1-27 added on Sat February 7 2015;chain:28-694 added on Sat February 7 2015 |
| _displayName | UniProt:Q9H461 FZD8 |
| _timestamp | 2024-11-03 19:56:22 |
| chain | signal peptide:1-27 chain:28-694 |
| checksum | E740CBFDA2A233EF |
| comment | FUNCTION Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.SUBUNIT Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by DKK1. Interacts with GPOC, RSPO1 and RSPO3 (By similarity). Interacts with glypican GPC3 (PubMed:24496449).INTERACTION Colocalizes with GOPC at the Golgi apparatus.TISSUE SPECIFICITY Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.DOMAIN The PDZ-binding motif mediates interaction with GOPC.DOMAIN Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.DOMAIN The FZ domain is involved in binding with Wnt ligands.PTM Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.SIMILARITY Belongs to the G-protein coupled receptor Fz/Smo family. |
| description | recommendedName: Frizzled-8 shortName: Fz-8 shortName: hFz8 |
| geneName | FZD8 |
| identifier | Q9H461 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Developmental protein Disulfide bond G-protein coupled receptor Glycoprotein Golgi apparatus Membrane Proteomics identification Receptor Reference proteome Signal Transducer Transmembrane Transmembrane helix Ubl conjugation Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | FZD8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991273] ENSEMBL:ENSG00000177283 FZD8 [Homo sapiens] |
| secondaryIdentifier | FZD8_HUMAN |
| sequenceLength | 694 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:443947] FZD8 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:4641183] ub-FZD8 [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:4641186] ubiquitinylated lysine at unknown position |
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No pathways have been reviewed or authored by UniProt:Q9H461 FZD8 (55180)
