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Details on Person UniProt:P58549 FXYD7
| Class:Id | ReferenceGeneProduct:55154 |
|---|---|
| _chainChangeLog | chain:1-80 added on Sat February 7 2015 |
| _displayName | UniProt:P58549 FXYD7 |
| _timestamp | 2024-11-03 20:00:58 |
| chain | chain:1-80 |
| checksum | 130DAC482EFF1939 |
| comment | FUNCTION Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:33231612). Reduces the apparent affinity for external K(+), an effect that depends on the presence of external Na(+) and voltage (PubMed:33231612). Increases the apparent affinity for intracellular Na(+) (PubMed:33231612).SUBUNIT Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and a FXYD regulatory unit that modulates the enzymatic activity in a tissue- and isoform-specific way by changing affinities of the Na+/K+-ATPase toward Na(+), K(+) or ATP.INTERACTION Able to translocate to the plasma membrane independent of its association with NKA (in vitro).DOMAIN The transmembrane domain is important for the interaction with NKA and with the functional effect of FXYD7.PTM O-glycosylated; required for stabilization and translocation to the plasma membrane.SIMILARITY Belongs to the FXYD family. |
| description | recommendedName: FXYD domain-containing ion transport regulator 7 |
| geneName | FXYD7 |
| identifier | P58549 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Glycoprotein Ion transport Membrane Phosphoprotein Potassium Potassium transport Proteomics identification Reference proteome Sodium Sodium transport Sodium/potassium transport Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | FXYD7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996578] ENSEMBL:ENSG00000221946 FXYD7 [Homo sapiens] |
| secondaryIdentifier | FXYD7_HUMAN |
| sequenceLength | 80 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:2752082] FXYD7 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P58549 FXYD7 (55154)
