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Details on Person UniProt:Q9H4M3 FBXO44
| Class:Id | ReferenceGeneProduct:55066 |
|---|---|
| _chainChangeLog | chain:1-255 added on Sat February 7 2015 |
| _displayName | UniProt:Q9H4M3 FBXO44 |
| _timestamp | 2026-02-20 22:54:28 |
| chain | chain:1-255 |
| checksum | 3DA167B70E22A7E8 |
| comment | FUNCTION Substrate-recognition component of two distinct E3 ligase complexes, the SKP1-CUL1-FBXO44 complex and the CUL4B-DDB1-FBXO44 complex (PubMed:18203720, PubMed:25970626). The complex SCF(FBXO44) complex ubiquitinates and mediates BRCA1 degradation (PubMed:23086937). In association with cullin 4B/CUL4B and DDB1, mediates the ubiquitination of RGS2 leading to its degradation (PubMed:25970626). Additionally, regulates the pregnane X receptor/NR1I2 protein level by ubiquitination and degradation (PubMed:37969738).SUBUNIT Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1. Interacts with CUL4B and DDB1 (PubMed:25970626). Interacts wwith BRCA1; this interaction mediates BRCA1 ubiquitination and subsequent degradation (PubMed:23086937). Interacts with RGS2; this interaction mediates RGS2 ubiquitination and subsequent degradation (PubMed:25970626). Interacts with PXR/NR1I2; this interaction mediates PXR/NR1I2 ubiquitination and subsequent degradation (PubMed:37969738).INTERACTION Abundantly expressed in brain and kidney. Expressed at lower levels in heart, spleen and liver.MISCELLANEOUS In contrast to other FBA domain containing proteins, FBXO44 demonstrates no significant binding to any of the 200 glycans tested.ONLINE INFORMATION FLAG-FBG3 |
| description | recommendedName: F-box only protein 44 alternativeName: F-box protein FBX30 alternativeName: F-box/G-domain protein 3 |
| geneName | FBXO44 FBG3 FBX30 FBX44 FBX6A FBXO6A |
| identifier | Q9H4M3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Nucleus Proteomics identification Reference proteome Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | FBXO44 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999481] ENSEMBL:ENSG00000132879 FBXO44 [Homo sapiens] |
| secondaryIdentifier | FBX44_HUMAN B3KNZ2 B7Z743 Q5TGX2 Q5TGX4 Q5TGX5 Q68DJ9 Q8WWY2 |
| sequenceLength | 255 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:147536] UniProt:Q9H4M3-2 FBXO44 [Homo sapiens] [ReferenceIsoform:414253] UniProt:Q9H4M3-1 FBXO44 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:976031] FBXO44 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9H4M3 FBXO44 (55066)
