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Details on Person UniProt:O75896 TUSC2
| Class:Id | ReferenceGeneProduct:55034 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-110 added on Fri February 6 2015;initiator methionine:1 for 55034 removed on Fri Nov 03 2023;initiator methionine: for 55034 added on Fri Nov 03 2023;initiator methionine: for 55034 removed on Fri Aug 15 2025;initiator methionine:1 for 55034 added on Fri Aug 15 2025 |
| _displayName | UniProt:O75896 TUSC2 |
| _timestamp | 2025-08-15 21:35:00 |
| chain | initiator methionine:1 chain:2-110 |
| checksum | 9503BD10637C1504 |
| comment | FUNCTION May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.INTERACTION Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.PTM Myristoylation is required for tumor suppressor activity.SIMILARITY Belongs to the TUSC2 family. |
| description | recommendedName: Tumor suppressor candidate 2 alternativeName: Fusion 1 protein shortName: Fus-1 protein alternativeName: PDGFA-associated protein 2 |
| geneName | TUSC2 C3orf11 FUS1 LGCC PDAP2 |
| identifier | O75896 |
| isSequenceChanged | FALSE |
| keyword | Cell cycle Lipoprotein Myristate Phosphoprotein Proteomics identification Reference proteome Tumor suppressor |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TUSC2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962397] ENSEMBL:ENSG00000114383 TUSC2 [Homo sapiens] |
| secondaryIdentifier | TUSC2_HUMAN B2R4Y9 |
| sequenceLength | 110 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5667136] TUSC2 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O75896 TUSC2 (55034)
