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Details on Person UniProt:O75891 ALDH1L1
| Class:Id | ReferenceGeneProduct:55022 |
|---|---|
| _chainChangeLog | chain:1-902 added on Sat February 7 2015 |
| _displayName | UniProt:O75891 ALDH1L1 |
| _timestamp | 2025-02-21 19:35:24 |
| chain | chain:1-902 |
| checksum | D92CB2930617F7CF |
| comment | FUNCTION Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:19933275, PubMed:21238436). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity).CATALYTIC ACTIVITY (6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)SUBUNIT Homotetramer.INTERACTION Highly expressed in liver, pancreas and kidney.DOMAIN The N-terminal hydrolase domain has an NADP-independent formyltetrahydrofolate hydrolase activity, releasing formate and tetrahydrofolate.DOMAIN The C-terminal aldehyde dehydrogenase domain has an NADP-dependent dehydrogenase activity. It catalyzes the oxidation of formate, released by the hydrolysis of formyltetrahydrofolate, into CO2.DOMAIN The carrier domain is phosphopantetheinylated and uses the 4'-phosphopantetheine/4'-PP swinging arm to transfer the formyl group released by the N-terminal formyltetrahydrofolate hydrolase activity to the C-terminal aldehyde dehydrogenase domain that catalyzes its NADP-dependent oxidation into CO2. The overall NADP-dependent physiological reaction requires the 3 domains (N-terminal hydrolase, C-terminal aldehyde dehydrogenase and carrier domains) to convert formyltetrahydrofolate into tetrahydrofolate and CO2.PTM Phosphopantetheinylation at Ser-354 by AASDHPPT is required for the formyltetrahydrofolate dehydrogenase activity.SIMILARITY In the N-terminal section; belongs to the GART family.SIMILARITY In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. |
| description | recommendedName: fullName evidence="16"Cytosolic 10-formyltetrahydrofolate dehydrogenase shortName: 10-FTHFDH shortName evidence="13"FDH ecNumber evidence="7 9"1.5.1.6 alternativeName: fullName evidence="17"Aldehyde dehydrogenase family 1 member L1 |
| geneName | ALDH1L1 FTHFD |
| identifier | O75891 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm NADP One-carbon metabolism Oxidoreductase Phosphopantetheine Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ALDH1L1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994041] ENSEMBL:ENSG00000144908 ALDH1L1 [Homo sapiens] |
| secondaryIdentifier | AL1L1_HUMAN B4DG36 E9PBX3 Q68CS1 Q8TBP8 |
| sequenceLength | 902 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8972692] UniProt:O75891-1 ALDH1L1 [Homo sapiens] [ReferenceIsoform:8972693] UniProt:O75891-2 ALDH1L1 [Homo sapiens] [ReferenceIsoform:8972694] UniProt:O75891-3 ALDH1L1 [Homo sapiens] [ReferenceIsoform:8972695] UniProt:O75891-4 ALDH1L1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6808507] ALDH1L1 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:6808486] O-phosphopantetheine-L-serine at 354 |
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No pathways have been reviewed or authored by UniProt:O75891 ALDH1L1 (55022)
