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Details on Person UniProt:O95954 FTCD
| Class:Id | ReferenceGeneProduct:55020 |
|---|---|
| _chainChangeLog | chain:1-541 added on Sat February 7 2015 |
| _displayName | UniProt:O95954 FTCD |
| _timestamp | 2025-02-21 19:06:52 |
| chain | chain:1-541 |
| checksum | C6CFEBFC6DC2ED68 |
| comment | FUNCTION Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.FUNCTION Binds and promotes bundling of vimentin filaments originating from the Golgi.CATALYTIC ACTIVITY 5-formimidoyltetrahydrofolate + L-glutamate = N-formimidoyl-L-glutamate + (6S)-5,6,7,8-tetrahydrofolateCATALYTIC ACTIVITY 5-formimidoyltetrahydrofolate + 2 H(+) = (6R)-5,10-methenyltetrahydrofolate + NH4(+)BIOPHYSICOCHEMICAL PROPERTIES Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.SUBUNIT Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.INTERACTION More abundantly located around the mother centriole.ALTERNATIVE PRODUCTS The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.SIMILARITY In the N-terminal section; belongs to the formiminotransferase family. |
| description | recommendedName: fullName evidence="9"Formimidoyltransferase-cyclodeaminase alternativeName: Formiminotransferase-cyclodeaminase shortName: FTCD alternativeName: LCHC1 domain recommendedName: fullName evidence="9"Glutamate formimidoyltransferase ecNumber evidence="5"2.1.2.5 alternativeName: Glutamate formiminotransferase alternativeName: Glutamate formyltransferase /domain domain recommendedName: fullName evidence="3"Formimidoyltetrahydrofolate cyclodeaminase ecNumber evidence="3"4.3.1.4 alternativeName: Formiminotetrahydrofolate cyclodeaminase /domain |
| geneName | FTCD |
| identifier | O95954 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Cytoskeleton Disease variant Folate-binding Golgi apparatus Histidine metabolism Lyase Multifunctional enzyme Phosphoprotein Proteomics identification Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | FTCD |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004115] ENSEMBL:ENSG00000160282 FTCD [Homo sapiens] |
| secondaryIdentifier | FTCD_HUMAN B9EGD0 Q86V03 Q9HCT4 Q9HCT5 Q9HCT6 Q9UHJ2 |
| sequenceLength | 541 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:147460] UniProt:O95954-2 FTCD [Homo sapiens] [ReferenceIsoform:147461] UniProt:O95954-3 FTCD [Homo sapiens] [ReferenceIsoform:147462] UniProt:O95954-4 FTCD [Homo sapiens] [ReferenceIsoform:402195] UniProt:O95954-1 FTCD [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:70907] FTCD [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95954 FTCD (55020)
