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Details on Person UniProt:O95633 FSTL3
| Class:Id | ReferenceGeneProduct:55016 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Sat February 7 2015;chain:27-263 added on Sat February 7 2015 |
| _displayName | UniProt:O95633 FSTL3 |
| _timestamp | 2024-11-03 20:00:57 |
| chain | signal peptide:1-26 chain:27-263 |
| checksum | 6A9AB86ADD4FD09C |
| comment | FUNCTION Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.SUBUNIT Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Isoform 2 interacts with MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN.INTERACTION Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to.ALTERNATIVE PRODUCTS Expressed in a wide range of tissues.DISEASE A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. |
| description | recommendedName: Follistatin-related protein 3 alternativeName: Follistatin-like protein 3 alternativeName: Follistatin-related gene protein |
| geneName | FSTL3 FLRG UNQ674/PRO1308 |
| identifier | O95633 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative initiation Chromosomal rearrangement Direct protein sequencing Disulfide bond Glycoprotein Nucleus Osteogenesis Phosphoprotein Proteomics identification Proto-oncogene Reference proteome Repeat Secreted Signal Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | FSTL3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004114] ENSEMBL:ENSG00000070404 FSTL3 [Homo sapiens] |
| secondaryIdentifier | FSTL3_HUMAN A8K7E3 |
| sequenceLength | 263 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8973781] UniProt:O95633-1 FSTL3 [Homo sapiens] [ReferenceIsoform:8973782] UniProt:O95633-2 FSTL3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:2473199] FSTL3 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8956703] FSTL3 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:8956915] p-FSTL3 [endoplasmic reticulum lumen] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8957055] phosphorylated residue at unknown position |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O95633 FSTL3 (55016)
