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Details on Person UniProt:P01225 FSHB
| Class:Id | ReferenceGeneProduct:55010 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Sat February 7 2015;chain:19-129 added on Sat February 7 2015 |
| _displayName | UniProt:P01225 FSHB |
| _timestamp | 2024-11-03 20:05:25 |
| chain | signal peptide:1-18 chain:19-129 |
| checksum | 9D2AF00DD76B8E2B |
| comment | FUNCTION Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:24692546, PubMed:2494176). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432).SUBUNIT Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.INTERACTION Efficient secretion requires dimerization with CGA.DISEASE The disease is caused by variants affecting the gene represented in this entry.PHARMACEUTICAL Available under the names Gonal-F or Metrodin HP (Serono) and Puregon (Organon). Used in the treatment of infertility in women with proven hypopituitarism or who have not responded to clomifene; or in superovulation treatment for assisted conception (such as in vitro fertilization). Metrodin HP is also used in the treatment of hypogonadotrophic hypogonadism in men for the stimulation of spermatogenesis.SIMILARITY Belongs to the glycoprotein hormones subunit beta family.ONLINE INFORMATION Follicle-stimulating hormone entry |
| description | recommendedName: Follitropin subunit beta alternativeName: Follicle-stimulating hormone beta subunit shortName: FSH-B shortName: FSH-beta alternativeName: Follitropin beta chain |
| geneName | FSHB |
| identifier | P01225 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hormone Hypogonadotropic hypogonadism Pharmaceutical Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | FSHB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993630] ENSEMBL:ENSG00000131808 FSHB [Homo sapiens] |
| secondaryIdentifier | FSHB_HUMAN A2TF08 A5JVV3 Q14D61 |
| sequenceLength | 129 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:378993] FSHB [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P01225 FSHB (55010)
