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Details on Person UniProt:P19883 FST
| Class:Id | ReferenceGeneProduct:55002 |
|---|---|
| _chainChangeLog | signal peptide:1-29 added on Sat February 7 2015;chain:30-344 added on Sat February 7 2015 |
| _displayName | UniProt:P19883 FST |
| _timestamp | 2025-05-21 21:05:23 |
| chain | signal peptide:1-29 chain:30-344 |
| checksum | D9BB45055D84AC90 |
| comment | FUNCTION Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs) (PubMed:11279126, PubMed:16482217, PubMed:18535106). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling (PubMed:16482217). Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin (By similarity). Also promotes neural differentiation by antagonizing the action BMP4 (By similarity). Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA (PubMed:11279126). On the other hand, translocates into the nucleus where it down-regulates rRNA synthesis and ribosome biogenesis to maintain cellular energy homeostasis by binding to rDNA.SUBUNIT Interacts with GDF11 (PubMed:18535106, PubMed:28257634). Interacts with activin A/INHBA (PubMed:11279126, PubMed:16482217, PubMed:18535106, PubMed:16198295, PubMed:17409095). Interacts with MYOSTATIN/MSTN (PubMed:18535106).INTERACTION Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme (PubMed:31215115).INDUCTION By glucose deprivation. |
| description | recommendedName: fullName evidence="19"Follistatin shortName: FS alternativeName: fullName evidence="1"Activin-binding protein |
| geneName | FST |
| identifier | P19883 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Nucleus Proteomics identification Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | FST |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991860] ENSEMBL:ENSG00000134363 FST [Homo sapiens] |
| secondaryIdentifier | FST_HUMAN B5BU94 Q9BTH0 |
| sequenceLength | 344 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:147450] UniProt:P19883-2 FST [Homo sapiens] [ReferenceIsoform:403204] UniProt:P19883-1 FST [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:2473211] FST [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P19883 FST (55002)
