Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Expression of NR1D1 (REV-ERBA)

Class:Id	BlackBoxEvent:549475
_displayName	Expression of NR1D1 (REV-ERBA)
_doRelease	TRUE
_timestamp	2025-02-19 18:26:32
authored	[InstanceEdit:549443] May, B, 2010-03-19
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:549380] May, B, 2010-03-21
edited	[InstanceEdit:549443] May, B, 2010-03-19
inferredFrom	[BlackBoxEvent:549505] Expression of Nr1d1 (Rev-erba) [Mus musculus]
input	[EntityWithAccessionedSequence:5641202] NR1D1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:549377] Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus [LiteratureReference:1480013] A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity
modified	[InstanceEdit:766127] May, B, 2010-05-21 [InstanceEdit:847704] May, B, 2010-05-30 [InstanceEdit:879757] May, B, 2010-06-23 [InstanceEdit:927716] May, B, 2010-08-06 [InstanceEdit:1801593] May, B, 2011-10-24 [InstanceEdit:2084234] May, B, 2012-01-30 [InstanceEdit:5641233] May, Bruce, 2014-11-16 [InstanceEdit:5663195] May, Bruce, 2015-01-15 [InstanceEdit:5663298] May, Bruce, 2015-01-17 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626999] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9707568] Stephan, Ralf, 2020-11-19 [InstanceEdit:9713328] Stephan, Ralf, 2021-01-25 [InstanceEdit:9717154] May, Bruce, 2021-03-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9938770] May, Bruce, 2025-02-19
name	Expression of NR1D1 (REV-ERBA) NRID1 gene produces NRID1
output	[EntityWithAccessionedSequence:375499] NR1D1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9923010] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene [Homo sapiens] [BlackBoxEvent:9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:549554] Positive gene expression regulation by 'p-BMAL1:p-CLOCK,NPAS2:NR1D1 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:1480006] Negative gene expression regulation by 'NR1D1:heme:Corepressors:NR1D1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:1480011] Positive gene expression regulation by 'RORA:Coactivator:NR1D1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642019] Positive gene expression regulation by 'RORA:Coactivator:NR1D1 gene [nucleoplasm]' Transcriptional regulation of human Rev-erbalpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha [RegulationReference:9642260] Negative gene expression regulation by 'NR1D1:heme:Corepressors:NR1D1 gene [nucleoplasm]' A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity
releaseDate	2010-09-21
reviewed	[InstanceEdit:422151] D'Eustachio, P, 2009-05-26 22:13:22 [InstanceEdit:879756] Albrecht, Urs, 2010-06-23 [InstanceEdit:879726] Kay, SA, 2010-06-23 [InstanceEdit:879790] Hirota, T, 2010-06-23 [InstanceEdit:879786] Delaunay, F, 2010-06-23 [InstanceEdit:9713327] Somers, Julia, 2021-01-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105242] R-HSA-549475.9
summation	[Summation:549539] The NR1D1 (REV-ERBA) gene is transcribed to yield mRNA and t... [Summation:1480022] As inferred from mouse, RORA binds RRE DNA elements and recr... [Summation:549552] Activation of NR1D1 (REV-ERBA) expression by phosphorylated ...
(hasEvent)	[Pathway:9707616] Heme signaling [Homo sapiens]
(precedingEvent)	[Reaction:1368069] NR1D1 (REV-ERBA) binds heme, the BMAL1 (ARNTL) gene, and recruits corepressors [Homo sapiens] [Reaction:5663245] NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors [Homo sapiens] [Reaction:5663252] NR1D1 (REV-ERBA) binds heme, the ELOVL3 gene, and recruits corepressors [Homo sapiens] [Reaction:5663258] NR1D1 (REV-ERBA) binds heme, the PPARGC1A gene, and recruits corepressors [Homo sapiens] [Reaction:5663265] NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors [Homo sapiens] [Reaction:5663271] NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors [Homo sapiens]
(replacementInstances)	[_Deleted:9032440] Deletion of instance: 5334727
(updatedInstance)	[_UpdateTracker:9775625] Update Tracker - [BlackBoxEvent:549475] Expression of NR1D1 (REV-ERBA) - v78:[addSummation] [_UpdateTracker:9776238] Update Tracker - [BlackBoxEvent:549475] Expression of NR1D1 (REV-ERBA) - v77:[modifyText] [_UpdateTracker:9776302] Update Tracker - [BlackBoxEvent:549475] Expression of NR1D1 (REV-ERBA) - v76:[modifyText] [_UpdateTracker:9785285] Update Tracker - [BlackBoxEvent:549475] Expression of NR1D1 (REV-ERBA) - v52:[add_removeRegulator] [_UpdateTracker:9785860] Update Tracker - [BlackBoxEvent:549475] Expression of NR1D1 (REV-ERBA) - v51:[addInput] [_UpdateTracker:9787292] Update Tracker - [BlackBoxEvent:549475] Expression of NR1D1 (REV-ERBA) - v46:[modifyText] [_UpdateTracker:9788796] Update Tracker - [BlackBoxEvent:549475] Expression of NR1D1 (REV-ERBA) - v40:[addLiteratureReference, add_removeRegulator, modifyText] [_UpdateTracker:9788894] Update Tracker - [BlackBoxEvent:549475] Expression of NR1D1 (REV-ERBA) - v39:[add_removeRegulator] [_UpdateTracker:9789492] Update Tracker - [BlackBoxEvent:549475] Expression of NR1D1 (REV-ERBA) - v38:[addRegulator]
[Change default viewing format]

No pathways have been reviewed or authored by Expression of NR1D1 (REV-ERBA) (549475)