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Details on Person The human gene SLC22A2 encodes the organic cation transporte...
| Class:Id | Summation:549324 |
|---|---|
| _displayName | The human gene SLC22A2 encodes the organic cation transporte... |
| _timestamp | 2016-08-01 12:12:50 |
| created | [InstanceEdit:549249] Jassal, Bijay, 2010-03-19 |
| modified | [InstanceEdit:706446] Jassal, Bijay, 2010-05-10 [InstanceEdit:8932953] Jassal, Bijay, 2016-08-01 |
| text | The human gene SLC22A2 encodes the organic cation transporter OCT2. It is expressed in a variety of tissues, especially the kidney and placenta. OCT2 can mediate the reversible transport of a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (Gorboulev et al. 1997). Pharmaceuticals that up-regulate OCT2 in the kidney can increase the renal excretion of cationic drugs. The transport activity of OCT2 was decreased upon co-expression of regulatory solute carrier protein family 1 member 1 (RSC1A1, aka RS1). RSC1A1 exhibits glucose-dependent, short-term inhibition of OCT2 by inhibiting the release of vesicles from the trans-Golgi network (Veyhl et al. 2006). |
| (summation) | [Reaction:549279] OCT2 mediates tubular uptake of organic cations in the kidney [Homo sapiens] [Reaction:561054] OCT2 mediates tubular secretion of organic cations in the kidney [Homo sapiens] |
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