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Details on Person OCT2 mediates tubular uptake of organic cations in the kidney

Class:Id	Reaction:549279
_displayName	OCT2 mediates tubular uptake of organic cations in the kidney
_doRelease	TRUE
_timestamp	2025-08-13 17:59:12
authored	[InstanceEdit:549249] Jassal, Bijay, 2010-03-19
catalystActivity	[CatalystActivity:549263] transmembrane transporter activity of SLC22A1,SLC22A2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:549249] Jassal, Bijay, 2010-03-19
crossReference	[DatabaseIdentifier:9958531] RHEA:73864 [DatabaseIdentifier:9956807] RHEA:73872 [DatabaseIdentifier:9958540] RHEA:73876 [DatabaseIdentifier:9958534] RHEA:73880 [DatabaseIdentifier:9958553] RHEA:73868 [DatabaseIdentifier:9958541] RHEA:73860 [DatabaseIdentifier:9958532] RHEA:73884 [DatabaseIdentifier:9958547] RHEA:32752 [DatabaseIdentifier:9958549] RHEA:74541 [DatabaseIdentifier:9958545] RHEA:72132
edited	[InstanceEdit:549249] Jassal, Bijay, 2010-03-19
input	[DefinedSet:549237] OCT2 substrates [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:374923] Cloning and characterization of two human polyspecific organic cation transporters [LiteratureReference:8932959] RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1
modified	[InstanceEdit:549331] Jassal, Bijay, 2010-03-19 [InstanceEdit:561081] Jassal, Bijay, 2010-03-25 [InstanceEdit:706450] Jassal, Bijay, 2010-05-10 [InstanceEdit:3065949] Jassal, Bijay, 2013-02-06 [InstanceEdit:8932953] Jassal, Bijay, 2016-08-01 [InstanceEdit:8934768] Jassal, Bijay, 2016-08-12 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9958546] Stephan, Ralf, 2025-06-23 [InstanceEdit:9963189] Stephan, Ralf, 2025-08-13
name	OCT2 mediates tubular uptake of organic cations in the kidney
negativePrecedingEvent	[NegativePrecedingEvent:9963165] Futile Cycle: MATEs mediate extrusion of xenobiotics [NegativePrecedingEvent:9963177] Futile Cycle: OCT1 transports organic cations out of hepatic cells [NegativePrecedingEvent:9963171] Futile Cycle: OCT2 mediates tubular secretion of organic cations in the kidney [NegativePrecedingEvent:9963168] Futile Cycle: OCT3 mediates renal clearance of organic cations
output	[DefinedSet:549266] OCT2 substrates [cytosol]
regulatedBy	[NegativeRegulation:8932861] Negative regulation by 'RSC1A1 [plasma membrane]'
releaseDate	2010-06-15
reverseReaction	[Reaction:561054] OCT2 mediates tubular secretion of organic cations in the kidney [Homo sapiens] [Reaction:549279] OCT2 mediates tubular uptake of organic cations in the kidney [Homo sapiens]
reviewed	[InstanceEdit:706449] He, L, 2010-05-10
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8932953] Jassal, Bijay, 2016-08-01
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104078] R-HSA-549279.5
summation	[Summation:549324] The human gene SLC22A2 encodes the organic cation transporte...
(hasEvent)	[Pathway:549127] SLC-mediated transport of organic cations [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963173] Futile Cycle: OCT2 mediates tubular uptake of organic cations in the kidney [NegativePrecedingEvent:9963183] Futile Cycle: OCT2 mediates tubular uptake of organic cations in the kidney [NegativePrecedingEvent:9963186] Futile Cycle: OCT2 mediates tubular uptake of organic cations in the kidney [NegativePrecedingEvent:9963188] Futile Cycle: OCT2 mediates tubular uptake of organic cations in the kidney
(reverseReaction)	[Reaction:561054] OCT2 mediates tubular secretion of organic cations in the kidney [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782936] Update Tracker - [Reaction:549279] OCT2 mediates tubular uptake of organic cations in the kidney - v58:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9787721] Update Tracker - [Reaction:549279] OCT2 mediates tubular uptake of organic cations in the kidney - v44:[add_removeLiteratureReference]
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