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Details on Person SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol

Class:Id	Reaction:549241
_displayName	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2025-06-23 09:25:58
authored	[InstanceEdit:549249] Jassal, Bijay, 2010-03-19
catalystActivity	[CatalystActivity:549225] secondary active transmembrane transporter activity of SLC22A4 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:549249] Jassal, Bijay, 2010-03-19
crossReference	[DatabaseIdentifier:9958566] RHEA:75844
edited	[InstanceEdit:549249] Jassal, Bijay, 2010-03-19
input	[SimpleEntity:549261] ERGT [extracellular region] [SimpleEntity:74113] Na+ [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:549265] Discovery of the ergothioneine transporter [LiteratureReference:5625678] An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis [LiteratureReference:5625677] SLC22A4 and RUNX1: identification of RA susceptible genes
modified	[InstanceEdit:549331] Jassal, Bijay, 2010-03-19 [InstanceEdit:706450] Jassal, Bijay, 2010-05-10 [InstanceEdit:5625621] Jassal, Bijay, 2014-10-06 [InstanceEdit:5663019] Jassal, Bijay, 2015-01-14 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9958565] Stephan, Ralf, 2025-06-23
name	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol
output	[SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:549260] ERGT [cytosol]
regulatedBy	[NegativeRegulation:5669078] Negative regulation by 'RUNX1 [plasma membrane]'
releaseDate	2010-06-15
reviewed	[InstanceEdit:706449] He, L, 2010-05-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105508] R-HSA-549241.4
summation	[Summation:549293] The human gene SLC22A4 encodes the ergothioneine transporter...
(hasEvent)	[Pathway:549127] SLC-mediated transport of organic cations [Homo sapiens] [Pathway:5619064] Defective SLC22A4 is implicated in rheumatoid arthritis (RA) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785079] Update Tracker - [Reaction:549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - v52:[addRegulator, modifyText] [_UpdateTracker:9785876] Update Tracker - [Reaction:549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - v51:[add_removeLiteratureReference, modifyText]
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