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Details on Person OCT1 transports organic cations into hepatic cells

Class:IdReaction:549129
_displayNameOCT1 transports organic cations into hepatic cells
_doReleaseTRUE
_timestamp2025-08-13 17:58:43
authored[InstanceEdit:549124] Jassal, Bijay, 2010-03-17
catalystActivity[CatalystActivity:549130] transmembrane transporter activity of OCT1 [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:549124] Jassal, Bijay, 2010-03-17
crossReference[DatabaseIdentifier:9958541] RHEA:73860
[DatabaseIdentifier:9958531] RHEA:73864
[DatabaseIdentifier:9958540] RHEA:73876
[DatabaseIdentifier:9958532] RHEA:73884
[DatabaseIdentifier:9958534] RHEA:73880
[DatabaseIdentifier:9958536] RHEA:35041
[DatabaseIdentifier:9958547] RHEA:32752
edited[InstanceEdit:549124] Jassal, Bijay, 2010-03-17
input[DefinedSet:549264] OCT1 substrates [extracellular region]
isChimericFALSE
literatureReference[LiteratureReference:549318] Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa)
[LiteratureReference:374923] Cloning and characterization of two human polyspecific organic cation transporters
modified[InstanceEdit:549249] Jassal, Bijay, 2010-03-19
[InstanceEdit:549331] Jassal, Bijay, 2010-03-19
[InstanceEdit:706450] Jassal, Bijay, 2010-05-10
[InstanceEdit:3065949] Jassal, Bijay, 2013-02-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9958535] Stephan, Ralf, 2025-06-22
[InstanceEdit:9958546] Stephan, Ralf, 2025-06-23
[InstanceEdit:9963189] Stephan, Ralf, 2025-08-13
nameOCT1 transports organic cations into hepatic cells
negativePrecedingEvent[NegativePrecedingEvent:9963170] Futile Cycle: MATEs mediate extrusion of xenobiotics
[NegativePrecedingEvent:9963169] Futile Cycle: OCT1 transports organic cations out of hepatic cells
[NegativePrecedingEvent:9963190] Futile Cycle: OCT2 mediates tubular secretion of organic cations in the kidney
[NegativePrecedingEvent:9963182] Futile Cycle: OCT3 mediates renal clearance of organic cations
output[DefinedSet:549250] OCT1 substrates [cytosol]
releaseDate2010-06-15
reverseReaction
reviewed[InstanceEdit:706449] He, L, 2010-05-10
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105319] R-HSA-549129.3
summation[Summation:549315] The human gene SLC22A1 expresses the organic cation transpor...
(hasEvent)[Pathway:549127] SLC-mediated transport of organic cations [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9963164] Futile Cycle: OCT1 transports organic cations into hepatic cells
[NegativePrecedingEvent:9963166] Futile Cycle: OCT1 transports organic cations into hepatic cells
[NegativePrecedingEvent:9963179] Futile Cycle: OCT1 transports organic cations into hepatic cells
[NegativePrecedingEvent:9963184] Futile Cycle: OCT1 transports organic cations into hepatic cells
(reverseReaction)[Reaction:549322] OCT1 transports organic cations out of hepatic cells [Homo sapiens]
(updatedInstance)[_UpdateTracker:9787635] Update Tracker - [Reaction:549129] OCT1 transports organic cations into hepatic cells - v44:[add_removeLiteratureReference]
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No pathways have been reviewed or authored by OCT1 transports organic cations into hepatic cells (549129)
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