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Details on Person G3P is acylated to 1-acyl LPA by AGPAT6

Class:Id	Reaction:549112
_displayName	G3P is acylated to 1-acyl LPA by AGPAT6
_doRelease	TRUE
_timestamp	2016-11-10 00:55:33
authored	[InstanceEdit:76232] Gopinathrao, G, 2003-10-02 00:00:00
catalystActivity	[CatalystActivity:1500613] glycerol-3-phosphate O-acyltransferase activity of AGPAT6 [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:549096] D'Eustachio, P, 2010-03-16
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:76114] G3P [cytosol] [SimpleEntity:1500578] acyl-CoA [cytosol]
literatureReference	[LiteratureReference:549091] Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis [LiteratureReference:549090] AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase [LiteratureReference:549097] Acyl-CoA:lysophospholipid acyltransferases
modified	[InstanceEdit:549119] D'Eustachio, P, 2010-03-16 [InstanceEdit:549122] D'Eustachio, P, 2010-03-16 [InstanceEdit:2063939] Williams, MG, 2012-01-18 [InstanceEdit:2230930] D'Eustachio, P, 2012-05-04 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	G3P is acylated to 1-acyl LPA by AGPAT6 glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated] Conversion of glycerol-3-phosphate to lysophosphatidic acid
output	[SimpleEntity:1500604] 1-acyl LPA [cytosol] [SimpleEntity:76194] CoA-SH [cytosol]
precedingEvent	[Reaction:75887] Conversion of Glycerol to Glycerol-3-phosphate [Homo sapiens] [Reaction:75889] DHAP is converted to G3P by GPD1/GPD1L [Homo sapiens] [Reaction:1483107] GPETA is hydrolyzed to ETA and G3P by GPCPD1 [Homo sapiens] [Reaction:1482571] 1-acyl LPE is hydrolyzed to GPETA by PLA2G4C [Homo sapiens] [Reaction:1482545] 2-acyl LPE is hydrolyzed to GPETA by PLA2G4C [Homo sapiens] [Reaction:1483116] GPCho is hydrolyzed to Cho and G3P by GPCPD1 [Homo sapiens] [Reaction:1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] [Homo sapiens] [Reaction:1482696] 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C [Homo sapiens] [Reaction:1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] [Homo sapiens] [Reaction:1482629] 2-acyl LPC is hydrolyzed to GPCho by PLA2G4C [Homo sapiens] [Reaction:8952251] PLA2G15 hydrolyses LPC to GPCho and LCFA(-) [Homo sapiens]
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104728] R-HSA-549112.3
summation	[Summation:549067] Glycerol-3-phosphate (G3P) is acylated to 1-acyl lysophospha...
(hasEvent)	[Pathway:1483166] Synthesis of PA [Homo sapiens]
(precedingEvent)	[Reaction:75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) [Homo sapiens] [Reaction:1482690] 1-acyl LPA is acylated to PA by LPAAT [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788578] Update Tracker - [Reaction:549112] G3P is acylated to 1-acyl LPA by AGPAT6 - v41:[modifyText, removeLiteratureReference] [_UpdateTracker:9788827] Update Tracker - [Reaction:549112] G3P is acylated to 1-acyl LPA by AGPAT6 - v40:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9789020] Update Tracker - [Reaction:549112] G3P is acylated to 1-acyl LPA by AGPAT6 - v39:[modifyText]
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