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Details on Person lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [Elovl4]

Class:Id	Reaction:548848
_displayName	lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [Elovl4]
_doRelease	TRUE
_timestamp	2024-05-21 16:55:59
authored	[InstanceEdit:548846] D'Eustachio, P, 2010-03-14
catalystActivity	[CatalystActivity:548850] fatty acid elongase activity of Elovl4 [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643772] fatty acid elongase activity of Elovl4 [endoplasmic reticulum membrane] Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:548851] D'Eustachio, P, 2010-03-14
edited	[InstanceEdit:699800] D'Eustachio, P, 2010-05-08
input	[SimpleEntity:548808] TCS-CoA [cytosol] [SimpleEntity:29508] Mal-CoA [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9907566] D'Eustachio, Peter, 2024-04-12
isChimeric	FALSE
literatureReference	[LiteratureReference:548665] Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids [LiteratureReference:548675] Dominant negative mechanism underlies autosomal dominant Stargardt-like macular dystrophy linked to mutations in ELOVL4
modified	[InstanceEdit:548852] D'Eustachio, P, 2010-03-14 [InstanceEdit:827349] Matthews, L, 2010-05-27 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20 [InstanceEdit:9910841] D'Eustachio, Peter, 2024-05-21
name	lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [Elovl4]
output	[SimpleEntity:548797] 3OHC-CoA [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:113528] CO2 [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2010-06-15
reviewed	[InstanceEdit:9907581] Hill, David P, 2024-04-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:1104920] R-MMU-548848.4
structureModified	[InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20
summation	[Summation:548849] Mouse elongation of very long chain fatty acids protein 4 (E...
(inferredFrom)	[Reaction:548830] ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9911086] Update Tracker - [Reaction:548848] lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [Elovl4] - v89:[addInput]
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No pathways have been reviewed or authored by lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH [Elovl4] (548848)