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Details on Person ACSL3,4 ligate CoA to AA to form AA-CoA

Class:IdReaction:548843
_displayNameACSL3,4 ligate CoA to AA to form AA-CoA
_doReleaseTRUE
_timestamp2015-02-21 22:32:05
authored[InstanceEdit:548846] D'Eustachio, P, 2010-03-14
catalystActivity[CatalystActivity:548838] long-chain fatty acid-CoA ligase activity of ACSL3,4 [endoplasmic reticulum membrane]
catalystActivityReference[CatalystActivityReference:9643588] long-chain fatty acid-CoA ligase activity of ACSL3,4 [endoplasmic reticulum membrane] A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:548837] D'Eustachio, P, 2010-03-14
edited[InstanceEdit:548846] D'Eustachio, P, 2010-03-14
input[SimpleEntity:29768] AA [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:76194] CoA-SH [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:548713] A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients
[LiteratureReference:548702] FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation
[LiteratureReference:5676169] Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells
modified[InstanceEdit:548844] D'Eustachio, P, 2010-03-14
[InstanceEdit:548845] D'Eustachio, P, 2010-03-14
[InstanceEdit:827349] Matthews, L, 2010-05-27
[InstanceEdit:5676168] Jassal, Bijay, 2015-02-19
[InstanceEdit:5678221] D'Eustachio, Peter, 2015-02-21
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameACSL3,4 ligate CoA to AA to form AA-CoA
arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4]
output[SimpleEntity:548819] AA-CoA [cytosol]
[SimpleEntity:76577] AMP [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:29356] H2O [cytosol]
releaseDate2010-06-15
reviewed[InstanceEdit:5678222] D'Eustachio, Peter, 2015-02-21
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5676160] Jassal, Bijay, 2015-02-19
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104735] R-HSA-548843.3
summation[Summation:548799] Acyl-CoA synthetase long-chain family member 4 (ACSL4) assoc...
(hasEvent)[Pathway:75876] Synthesis of very long-chain fatty acyl-CoAs [Homo sapiens]
(precedingEvent)[Reaction:548800] ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785086] Update Tracker - [Reaction:548843] ACSL3,4 ligate CoA to AA to form AA-CoA - v52:[addLiteratureReference, modifyText]
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