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Details on Person Elongation of very long chain fatty acids proteins 1, 4 (ELO...

Class:IdSummation:548835
_displayNameElongation of very long chain fatty acids proteins 1, 4 (ELO...
_timestamp2015-02-19 16:41:06
created[InstanceEdit:548837] D'Eustachio, P, 2010-03-14
modified[InstanceEdit:548844] D'Eustachio, P, 2010-03-14
[InstanceEdit:5676204] Jassal, Bijay, 2015-02-19
textElongation of very long chain fatty acids proteins 1, 4 (ELOVL1,4) catalyse the elongation of lignoceroyl-CoA (TCS-CoA) and malonyl-CoA (Mal-CoA) to form 3-oxocerotoyl-CoA (3OHC-CoA). ELOVL4 is abundant in retinal cells, where it is localized to the endoplasmic reticulum membrane (Grayson & Molday 2005). The catalytic activity of ELOVL4 has not been examined directly but is inferred from that of the homologous mouse protein, which is also active on polyunsaturated fatty acids (PUFAs) (PUFAs) (Agbada et al. 2008).
(summation)[Reaction:548830] ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA [Homo sapiens]
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